I would like to thank you folks for responding. The female bias of the diseases, the appearance of activity as lesions (ie. specific locations), and the fact that consistent specific genetic mutations have not been isolated, suggests some similarities in diseases like lupus, MS, and RA.
There is a project at http://www.madgc.org/
that is recruiting people who may have concurrent disorders. I am not in anyway associated with that but think it is an interesting approach to deciphering the disorders if, in fact, there is a genetic basis. I am leaning more towards epigenetic disruptions (disruption of the packaging/silencing/sequestering of genes) as being a primary event as opposed to specific gene mutations.