They indicate some drugs may already be on the market.
Future studies will evaluate the effects of therapies known to influence Treg cell function and FOXP3 expression, including TCR peptide vaccination and supplemental estrogen.
The combined effects on Treg expansion and activation induced by these distinct immunoregulatory approaches may account for their potent effects on clinical EAE and argue for a similar combined therapeutic approach for MS.
gwa wrote:This is the first time I have seen definite genes tied to MS.
I REALLY dont know what I am talking about, however, if I do happen to understand this correctly, I think the idea is once you know which genes are involved, you can then create a substance/chemical which could disable or down regulate the effect of those specific genes.viper498 wrote:Just because they find genes that make someone more likely to have MS doesn't mean you can some how eliminate that gene and cure the condition (or at least I wouldn't think).
Hi Brock,It still doesn't seem logical to me that they can treat MS until they know what the cause is. Just because they find genes that make someone more likely to have MS doesn't mean you can some how eliminate that gene and cure the condition (or at least I wouldn't think).
Hi Cure,Is 2010 when they expect to be ready to start testing in humans or is that when they expect there to actually be a treatment on the market? Does anyone know?
My wife is feeling well but the Tovaxin coordinator called her yesterday and said she had another new lesion on her recent MRI. While it's wonderful that she isn't experiencing anything bad from these lesions it's scaring the crap out of us that she keeps getting more of them. Dosing with Tovaxin hasn't yet begun and at this rate a possible year on placebo is getting scarier and scarier.I've not been feeling very well lately and that always makes me anxious to hear some good news.
Not to push the helminth parasites yet again but that is exactly what is most hopeful about them. They don't just suppress the immune system, they modulate it...controlling multiple aspects of the immune system as needed. Sorry, more shameless plugging of the helminths on my partI too am hopeful about some of the treatments in trials. It's obvious that completely supressing the immune system is not the answer.
Sorry Scooby, I feel so dumb! We rented a movie (Crank) and the family was yelling for me to get into the other room to watch it and I was in a hurry. If I remember correctly, you and Cure have the same or similar avatar and I evidently glossed over the name when I responded.scoobyjude wrote:Bob, I'll forgive you this time for calling me the wrong name but don't let it happen again!!
I'm a firm believer that the past is the clearest portal to the future. Some people don't look far enough into the past and have convinced themselves that because MS has never been cured in the past, it never will be. With a broader viewpoint of the past it's obvious that everything we set out to accomplish is eventually and invariably met with success. Sure a long, dark period always preceeds success but I'm convinced that we are at the tail end of the dark corridor...regarding stopping the disease process.It's easy to see how someone can become desperate when this disease is getting the best of them. That's why I couldn't possibly face another day if I didn't have hope that these days would end.
I was tempted to go and set my avtar to be the same as scoobyjude just to confuse you. Or even better, another one, so that both statements would be wrong!Lyon wrote:PS...I just checked. Cure has no avatar. My brain is mush.
Now that wouldn't be nice, considering that I'm clinging dearly to the little remaining sanity that I haveI was tempted to go and set my avtar to be the same as scoobyjude just to confuse you. Or even better, another one, so that both statements would be wrong! Twisted Evil
Guilty as charged! I read and think it's sinking in but by the time I get to play on the computer I'm so tired that my brain can't process the things that I read. Kind of a waste!She never actually reads these forums. just like you...
scoobyjude wrote:It's obvious that completely supressing the immune system is not the answer...
If they could develop a drug that would control MS without actually curing it, I'd be happy to take it for the rest of my life. I know that the ultimate goal is a cure but...
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