This Is MS Multiple Sclerosis Community: Knowledge & Support

Interesting answer about atrophy and axonal damage. Good to hear that research is very active in this area and work underway looking at neuro-protection. Sometimes when I read these sorts of answers, I'm still not clear if it is the myelin which is damaged first and then the axons, or the axons are damaged first resulting in secondary damage to the myelin!

http://www.msanswers.ca/QuestionView.aspx?L=2&QID=249

Ian

It is my understanding that it is the continuous damage to the myelin that ultimately destroys the axon. The myelin does regenerate, albeit weakly, for quite some time and than loses its ability and the axons become destroyed permanently. (God, what a lovely thought!)

Thanks Ian,
I should bookmark that site because it seems that guy quite consistantly answers interesting questions (or so it seems from your pointing it out).

Wouldn't it almost HAVE to be a situation in which the myelin goes first and then the axon? I've never seen any reason to think that it could happen the other way around.
Bob

Bob

But it apparently does...

Axonal loss in normal-appearing white matter in a patient with acute MS

Sharon

Hi Shayk,
I was going to ask you where you got those quotes but then I noticed that the text is a link. One of these days you're going to have to tell me how to do that!

I'll read it. Thanks!
Bob

Wow, I read it and it doesn't beat around the bush. In that case it seemed pretty conclusive. I'm going to have to think on this one because that's a big variation from what seems to be commonly accepted. I notice that is from 2001. I need to find out what other researchers make of it. Didn't seem in the time since to change what other researchers think?

Lyon, I'll be watching for Shayk's reply, too. Like you, I have wondered for a while how some folks (not only Shayk, but dignan and Napay, among others, I think) make a link with text.

This could probably be answered by Arron, too; but I have already asked him too many dumb questions, I'm embarrassed to ask him one more.

Hi Lynda,
Exactly, NAPAY does it too and I was going to ask her how earlier but I hadn't thought to ask until now.
Bob

Here's an example...

More BBCode formatting tips can be found here.
http://www.thisisms.com/forum-faq-bbcode.html

Note that using the above code for URLs keeps very long URLs from causing the browser page to stretch to a new width to accomodate the long URL. This can make reading a thread both annoying and difficult as it requires scrolling the window back and forth to read each line.

NHE

Thanks NHE and thanks for the link to the bbcode info. I never could have looked that up because I don't know what bbcode is and wouldn't have associated it with this situation. I think you mentioned this and "tinyurl" a long time ago and I didn't understand this part so I downloaded tinyurl. I like this option better!
Bob

bromley,

I have been watching this Australian company for several years. It is developing treatments for neuro degeneration and brain trauma repair.

The US FDA recently directed the company to enter stage 3 trials with their first drug, Glypromate, and put it on a fast track orphan drug status. Neuren is working on this med with the US Army Walter Reed Hospital brain trauma researchers.

This trial will further test brain repair for stroke victims and brain trauma patients and will end in 18 months.

Their next drug in their pipeline is NNZ 2566. This is an oral drug that penetrates the BBB and it will be used for axonal repair for brain trauma as well as multiple sclerosis. It is now in phase 2, or soon will be, and should be on the market in 4 to 5 years.

There is quite a lot of information on their site.

http://www.neurenpharma.com/

gwa

GWA,

Thanks - I've also been keeping tabs on this company. I think there is quite a bit of read across from the various CNS diseases where there is inflammation / neuro-degeneration. So a break-through in one disease should be beneficial to others. I recenlty saw that there is a small stem cell trial for people with Batten's disesase which will start at the end of the year. This is a grim degenerative disease, but hopefully it will show some success and pave the way for other human trials for other diseases of the CNS.

Ian

Anything that will protect/repair axons will benefit a lot of diseases.

gwa

NHE—Thanks so much for answering the question.

Bob

Generally speaking I think it most definitely has but not nearly enough IMO.

Here’s some 2006 research:

The contribution of demyelination to axonal loss in multiple sclerosis



Some 2005 research:

MRI Evidence for MS as a Diffuse Disease of the CNS
Ian

Just for you…..more on the potential of hormones. This is Alzheimer’s research and “allopregnanolone” is a metabolite of progesterone.

Therapeutic potential of neurogenesis for prevention and recovery from Alzheimer's disease: allopregnanolone as a proof of concept neurogenic agent
.

Take care all

Sharon

Hi Sharon, I haven't had a chance to read any more so I'm still as in the dark as I was last night.

I have to admit that I wouldn't know a Th1 from a Th2 response and 90% of the technical jargon I read is over my head.

What I do well is visualize and obsess. I take the abundance of possibilities (avoiding the things I don't have a chance of understanding) and run them through my head again and again a million times until things come together and make some kind of sense. Of course none of that results in provable fact...maybe untested and never to be tested theory would be the best description. I imagine that's what a lot of us do here.

Although it has nothing to do with what is or what isn't I'd really like to think that the myelin goes first and then the axon because with that being the case I can make sense of the relapsing/remitting aspect. I absolutely can't find any way to justify relapsing/remitting if the axon goes first.

I'll read up on it this weekend and give you my critique

I may have gotten the wrong idea but you seem to be pretty optomistic about this. If so, I don't need links, just make a convincing argument please.

Bob