gwa wrote:This is some of the worst news I have seen.
Our data parallel results from some of the clinical phase I/II studies showing continued clinical disease progression in multiple sclerosis patients with high expanded disability system scores despite autologous stem cell transplantation.
It's Barnett not Barrett. I've told you before.
I think I'll employ you at airports to uncover suspect packages. You have an amazing knack of sniffing out bad news stories related to MS (previous to this was the Rituxan PML story). Please post a good news MS story some time - it will be good for us and for you. I'm sure you're a positive sort of guy underneath. One infusion of Tysabri would do you the world of good.
I suppose, we have learnt that MS is not just about these lesions that we see on the scans, but that there's also involvement of other parts of the brain that actually appear normal and perhaps also the cortex, or the outer grey area of the brain, and this is just some studies from Hans Lassman in Vienna and really showing that there's quite a diffuse change within the white matter of the brain. So it's not just lesions.
Ian,bromley wrote:HZ, I'll be in Spain in four days time. Think of me sitting on the beach with a bottle of red wine and a beautiful woman. It could have been you if you'd played your cards right!
After the first open heart surgeries we could have decided that the percentages weren't there and it wasn't worth it but every aspect has improved since that time and people have triple bypass and return to work in a few days.
Many medical advancements have been made after initial failures
Err....didn't a certain someone offered to send me his wife's Valentine's card recently?I'm not even going to mention your offer to buy Dom chocolates!
The very first blood transfusions had a poor success rate and some catastrophic failures, all because some vital knowledge was missing, (about blood types), but the proof of principle had been established enough to encourage research into discovering why it sometimes didn't work. I think the proof of principle has been established with stem cells, so I hope a little setback won't be too much of a problem.
Just one more thought: when researchers publish their findings of a success, laboratories around the world try to replicate their work -- does the same thing happen when a "failure" is announced, or is it simply marked down as a dead end and thrown in the bin? If it is, some valuable lines of enquiry could be being discarded for want of a little extra knowledge.
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