Cure O and Dom
I really don’t understand why this is the first thing that comes to your minds.
One thing I find unusual about these hormone items, is that women have a considerably higher incidence of MS, yet, whenever you read of hormones helping MS, its a female based hormone
And even though I don’t understand your perspectives I’m going to make a few comments.
There has been speculation
that testosterone influences susceptibility to MS and that estrogen and progesterone (frequently thought of as female based hormones) provide neuroprotection. Hence, fewer men may actually get MS because of the influence of testosterone, but women may generally tend to have a less severe course because of the neuroprotection afforded by estrogen (and of course I personally think progesterone too but that seems to be mostly off the radar screen yet in MS research).
With regard to myelin specifically, don’t forget that testosterone was identified as the hormone that accounted for men (mice really) having thicker myelin than women.
But, my gut reaction to the statement that
whenever you read of hormones helping MS, it’s a female-based hormone
is “I don’t think so.”
I think testosterone was the first hormone out of the gate that demonstrated neuroprotective potential in men with MS. The Phase I testosterone trial improved cognitive functioning; decreased brain atrophy and increased brain derived neurotrophic factor (BDNF) in men with MS.
Two Phase I clinical trials of DHEA (another “male” hormone) were successful (trial participants included men and women).
Suffice it to say I think there’s evidence that typically male hormones (testosterone and DHEA) may potentially provide neuroprotection and/or help people manage MS and they are getting some attention.
Testosterone itself is gaining recognition for its neuroprotective properties. Testosterone Replacement Therapy for the Treatment of Neurological and Neuropsychiatric Disorders
. Neuroprotective Role of Testosterone in the Nervous System
(entire article available free)
And, I think we may be reading more about all hormones now that the presence of neurodegeneration in people with MS has been recognized as has an association with age and level of disability.
DHEA, estrogen, testosterone and progesterone all have seemingly potent and relevant neuroprotective properties and they all decline with age.
Just one reference to some of that, Neurosteroids as endogenous inhibitors of neuronal cell apoptosis in aging
The neuroactive steroids dehydroepiandrosterone (DHEA), its sulfate ester DHEAS, and allopregnanolone (Allo) are produced in the adrenals and the brain. Their production rate and levels in serum, brain, and adrenals decrease gradually with advancing age. The decline of their levels was associated with age-related neuronal dysfunction and degeneration, most probably because these steroids protect central nervous system (CNS) neurons against noxious agents.
The decline of neurosteroid levels during aging may leave the brain unprotected against neurotoxic challenges.
And, for inquiring minds, a free article on neurosteroids.
Endogenous Neuroprotective Factors: Neurosteroids
Sorry for the ramble. I was just startled by your perspectives and those are just some of the things I’ve read related to “male” hormones and MS. I definitely don't think it's all just about female hormones helping to manage MS. Why women are diagnosed with MS much more frequently than men is still an unanswered question I think.