Fine...I'm an old man whose time and smileys are short. I'm going to use the heck out of them until Arron prys them from my cold, dead fingersfinn wrote:Btw, I have decided to quit using smileys and give people an opportunity to interpret my posts just the way they want. I'd like to serve my humour dry.
I agree that MS in any stage or phase (even "CIS" and "benign") can be considered progressive but the existance of the separate definitions of PPMS and SPMS implies that some people don't go through the RRMS phase and instead collect $50 and go straight to PPMS.finn wrote: I'd suggest that our disease could always be called "progressive MS", a slowly progressive neurodegenerative process followed by demyelination. (thought you snuck that one by me eh?) When there is inflammation present in our CNS, the progression of neurodegeneration (and permanent disability) is slower, and the disease can be called RRMS (or SPMS).
I think it's a LOT more sensible to consider that EVERYONE goes through RRMS but around 10% (the 10% now diagnosed as PPMS) don't experience symptoms until the limits of plasticity are reached and symptoms become evident in the SPMS phase, rather than the "normal" RRMS phase.
Not a big deal in itself but the existance of the PPMS phase is just another misconception to needlessly complicate things.
Lyon wrote:So.....you are going to add another diamond and “simultaneous two-component” to your list?
Most likely there is an unknown relationship between the two of them, but I'd say the option is more or less covered when stated that "Inflammation and neurodegeneration are seperate and independent processes".[/quote]I somewhat agree finn but the "simultaneous" describes the fact that, whether separate or not, the inflammation and neurodegeneration are acting at the same time. On the other hand the "simultaneous" might hint that neurodegeneration and inflammation start at the same time and I don't want to touch that one because the information doesn't yet exist to prove either way.