Hi Lew,Loobie wrote: My question is this. It sounds to me that regardless of whether the "bad cells" are attacking myelin first or axons or whatever first, could it be assumed that the Tovaxin approach to neutralize the damaging cells has potential to work if either condition were present?
Hi Dom,Personally, when I think of neurodegeneration, I don't imagine axons, myelin, or oligodendrocytes actually being attacked by a rogue immune system, more that they decay and die off due to some other mechanism -- possibly premature apoptosis -- that leads to the overall loss of brain volume typical of MS.
TwistedHelix wrote:Tovaxin is aimed at getting rid of these T-cells by vaccinating against them, and looks like is going to be pretty successful in doing that. Whether neurodegeneration or T cells are the prime mover in MS, however, remains open to question. If both are present in the MS brain though, I should have thought that removing one of them can only help.
Lyon wrote:If Tovaxin is as effective as is being stated it would seem to prove that the traditional theory is true (myelin is attacked first which leaves the axons vulnerable) because if the axons were first to be attacked, saving the myelin wouldn't be very useful.
Hi Dom,TwistedHelix wrote:Your definition of atrophy fits in with the research which found that the impulses surging through an axon are part of the signalling pathway which calls in oligodendrocytes to myelinate, and support, the axon. The problem is, why does the axon reduce, and then stop, these impulses in the first place?
Hi Dom,TwistedHelix wrote: Bob, thanks again for the information you sent me: you've definitely got me convinced about helminths! Dom.[/i]
Hi Robin,raven wrote:In the two years post treatment I have regained approx. 3 EDSS points. Not conclusive evidence by any means, I may be a statistical anomaly. However given that this appears to be the norm with Campath treatment rather than the exception, one has to lend a certain weight to the results that cannot be given to the purely abductive hypothesis.
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