Myelin Repair Foundation Winter 2007 Update

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Myelin Repair Foundation Winter 2007 Update

Postby marcstck » Fri Mar 16, 2007 9:07 pm

Here's a link to the Myelin Repair Foundation's latest research update. Lots of good stuff, looks like they're making some real progress...

http://tinyurl.com/2jrk2z
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Postby Lyon » Sat Mar 17, 2007 9:14 am

Thanks Marc,
I originally thought it was a bad link. Couldn't get it to open on my other computer.
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Postby dignan » Sat Mar 17, 2007 9:36 am

marcstck, thanks for pointing this out to us. I have to share my favorite part of the report, given it's investigation into the role of the immune system.



Section IV – How is the immune response involved in damaging myelin or preventing its repair?
Section leader – Steve Miller

In earlier reports we showed that one critical component of the inflammatory immune response, interferon-gamma, appears to prevent myelin repair by triggering the endoplasmic reticulum (ER) stress response in oligodendrocytes. Ordinarily this ER stress response protects cells from damage but when the oligodendrocytes begin to produce massive quantities of myelin proteins, even a little additional stress is sufficient to kill them. Therefore we have been investigating ways to protect oligodendrocytes from anything that triggers the adverse effects of the ER stress response. Additionally, we have found that in adults the ER stress response can actually provide protection to oligodendrocytes against subsequent stresses through the activation of the integrated stress response (ISR), which is a general stress response. We have demonstrated this in mice by controlling a key gene necessary for ISR activation, and we have used brain tissue sections from mice to show that an experimental drug compound that prolongs the effects of the ISR can provide protection to oligodendrocytes against the adverse effects of interferon gamma. This project has now advanced to the point where a high throughput drug screen is being conducted at the National Drug Discovery Laboratory at the Harvard Center for Neurodegeneration and Repair to look for possible drug candidates that will have similar effects.

Previous MRF research progress reports discuss how dendritic cells have been found to penetrate the CNS in animal models of MS. These cells, along with memory and naïve T cells from the circulating blood that enter the inflamed CNS, result in the local activation of T cells specific for released fragments of myelin proteins called epitopes. This process is called epitope spreading and plays a major role in disease progression. Continued efforts have shown that myeloid dendritic cells are the primary subset present within demyelinated lesions and are responsible for activation of pro-inflammatory T cells that secret interferon gamma. Before we begin investigations into possible therapeutic approaches for targeting this critical antigen- presenting cell type, our animal studies are being expanded to include examination of human tissue from the Rocky Mountain MS Center to see if a similar pattern of myeloid dendritic cells is present in, or around, MS lesions. This study could provide considerable insight into the nature of the immune response in MS. Furthermore, selectively controlling their generation or migration, or their ability to stimulate a localized immune response, offers a new therapeutic approach to MS.

Continued investigations into combinatorial therapeutic approaches targeting both the underlying autoimmune response (using specific immunotherapeutic approaches) and promoting myelin repair for the treatment of established EAE have shown great promise. Combined short-term therapy using antibody fragments to block delivery of critical costimulatory signals required for T cell activation, along with a gamma secretase inhibitor which has been shown to promote myelination In Vitro, have demonstrated an ability to work synergistically to prevent disease relapses and promote recovery in mice with relapsing-remitting EAE.
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Myelin Repair Foundation Intro

Postby nicolem » Sat Mar 17, 2007 9:53 am

Good Day:

I wanted to introduce myself. I am with the Myelin Repair Foundation. I am the Volunteer Area Director for Colorado.

When you have a moment, please review our website below and take a peek at the interactive "launch video" on main page and play. It will help describe the foundation's purpose and little background for you. We have some recent news and updates which are featured on the left hand screen of the main page that you may want to view.

Looking forward to hearing from you.

Thank you,

Nicole A. McGarvey
Volunteer Area Director-Denver,CO
Myelin Repair Foundation http://myelinrepair.org/index.shtml
Discovery through collaboration
nicolemcgarvey@hotmail.com

Correspondence with representatives of the Myelin Repair Foundation should not replace consultation with one or more licensed neurologists or others who are trained to treat the symptoms of MS and other demyelinating diseases.
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Postby robbie » Sat Mar 17, 2007 10:07 am

In your estimation Nicole how long in years before i can get a prescription for a drug that fixes my myelin and gives me my life back. Just a rough estimate would be great...
Had ms for over 19 years now.
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Myelin Repair Foundation President Message

Postby nicolem » Mon Mar 26, 2007 12:45 pm

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Postby robbie » Mon Mar 26, 2007 1:01 pm

I think Bush has got a few extra billion laying around why don't you ask him :evil: Please don't tell me that lack of money needed to complete research is any reason why this can't go forward, this makes me so f@#king mad ...Just do it and fix us!!!
Had ms for over 19 years now.
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Postby nicolem » Mon Mar 26, 2007 6:41 pm

I understand your frustration...my brother who is in his mid 40's has Primary Progressive MS and is rapidly declining in his health. I have been in a caretaker role watching this horrible disease and want to see a cure also. We appreciate your comments and will do our best to work with our worldwide scientists and researchers for an answer-we all want that.


Thank you,

Nicole A. McGarvey
Volunteer Area Director-Denver,CO
Myelin Repair Foundation http://myelinrepair.org/index.shtml
Discovery through collaboration
nicolemcgarvey@hotmail.com

Correspondence with representatives of the Myelin Repair Foundation should not replace consultation with one or more licensed neurologists or others who are trained to treat the symptoms of MS and other demyelinating diseases.
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Postby Rita » Tue Mar 27, 2007 7:40 am

Robin, I think this is the kind of the people that we need, they are trying very hard to look for something that really hits this disease in their basis not like “others” that investigate about symptoms and relapses so you are in their treatment all your life. And they are working with a very qualified investigators.
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MRF Podcast with Scott Johnson and Dr. Bob Miller

Postby nicolem » Tue Mar 27, 2007 9:54 am

This link will take you to an interesting and informative March 24th interview Scott and Dr. Miller did with host Marc Pelletier of Futures in Biotech. It's about 1 hour. I think the interview was conducted in a way that would make it interesting to both scientists and MS novices.
http://www.twit.tv/FIB
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