14 years ago at HQ of one huge pharmaceutical company in Europe I was asked what do I think about monoclonal antibodies agaist MS. My answer was - it will not work properly. This was totally unexpected, "Jees, we just bought the company", and we changed the topic.
Well, now we got patients treated with 2 kinds of MNA. Either one reduce the rate of relapses (as other "autoimmunity" drugs do), numbers vary, official site of Tysabry says - one third, other sources - up to two thirds. Disability increased at the same rate as untreated.
I can expect that in a long run the disability would be even greater after MNA use because of more intensive scarification of lesions. I post somewhere here the timeline of axonal death -8-10 years, so this must be evaluated in a longer period trial, say at least 5-6 years.
If you remove the part of natural immune response from the brain, you alter the natural course of healing. Everyone with MS have heard about "miraculous" cases, when people with MS recover after being severely disabled for a long time. We a talking about axonal surviving here.
Anyway, when we talk about treatment options it is your choice. I am not against drugs, I stand for their PROPER use.
And there is always hope