How myelin gets mistaken

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How myelin gets mistaken

Postby TwistedHelix » Fri Mar 30, 2007 7:36 am

The following link to a PubMed abstract contains the usual impenetrable jargon. Here is my attempt at translation:

Two of the amino acids on a ligand, (docking molecule), of myelin basic protein are in the wrong position. They are necessary to bind with receptors on the surface of T-cells so that the myelin is not mistaken as "foreign".
Because they do not engage correctly with the T-cell, the myelin basic protein is misrecognised.
Here is the abstract:

tinyURL

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Postby daisy » Fri Mar 30, 2007 3:36 pm

Dom - I always get a lot out of your posts. Thanks for taking the time to share your research with the forum! Daisy
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Postby TwistedHelix » Sat Mar 31, 2007 5:31 am

Thanks Daisy,

I usually try and fumble my way through the jargon to see if I can extract some meaning from these abstracts, but I'm not a scientist, so don't always take my word for it! I always half-expect someone to reply with a post pointing out that I've got everything wrong!

In this particular extract it looks as if they found a reason, (hopefully "the" reason), why T cells mistake myelin for foreign tissue. If so, this could be an important step forward,

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