Now you got me even more confused. How they would have even been able to measure the effectiveness of a disease modifying drug in a very small subgroup of MS patients who "usually didn't survive 1,5-2 years"?TonyJegs wrote:1. Yes, they could be of some benefit for aggressive MS with rapid progression, the number of patients with this form is very small, they usually didn’t survive 1,5-2 years.
Actually, it seems to be. And as far as I know, there are already other animal models for MS, but they are not used as often as EAE. What do you think about them?TonyJegs wrote:2. I think it is possible to create an animal model mimic human MS, other question is why it is not in agenda of any current research?
Yes, and Parkinson's disease is much bigger business than MS, too. But still, I think the four billion dollar annual turnover of MS drugs is quite a lot.TonyJegs wrote:3. MS is a ‘drop in a bucket’ compare Alzheimer Disease.
Well, Einstein was a genious, but it seems like most MS-researchers might not be that smart ;-) Seriously, I'm sure that researchers working as a group could achieve more than the same amount of people working independently.TonyJegs wrote:4. Einstein used pencil and piece of paper. I don’t think that huge team of different specialists will work better, they will never understand each other completely.
I'd say it depends on the component ;-) I personally think the solution might turn out to be much simplier than thought.TonyJegs wrote:5. There are thousands of active compounds involved during damage-repair cycle. I don’t believe that single component could change it much.
I don't consider alternatives discouraging. What I find discouraging is research continuing exactly as it has in the past even though it's obvious that we aren't making great progress. I think there are some interesting treatment options in the works but that is more the luck of the draw than gain from knowledge. Throw enough chemicals at MS over a long enough period of time and sooner or later the odds will throw you one which shows a little benefit.
Lyon wrote:Not to nit pick but by "reverse of MS" you're referring to a two part process? Stopping the MS disease process and aiding the healing process?
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