Statins and Niacin both help with Cholesterol, but I have read nowhere that for multiple sclerosis they work on the same chemical pathways. B3 may help MS as well as Statins, but that does not mean they are interchangeable.jimmylegs wrote:vitamin b3 can also be used as an alternative to statins. looks like combining the two might not be a great idea:
http://www.prevention.com/article/0,577 ... -1,00.html
Protecting Axonal Degeneration by Increasing Nicotinamide Adenine Dinucleotide Levels in Experimental Autoimmune Encephalomyelitis Models
Shinjiro Kaneko,1 Jing Wang,1 Marie Kaneko,1 Glenn Yiu,1 Joanna M. Hurrell,1 Tanuja Chitnis,2 Samia J. Khoury,2 and Zhigang He1
1Division of Neuroscience, Children's Hospital Boston, Harvard Medical School, and 2Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115
Correspondence should be addressed to Zhigang He, Division of Neuroscience, Children's Hospital Boston, Enders #379, 320 Longwood Avenue, Boston, MA 02115. Email: email@example.com
Axonal damage is a major morphological alteration in the CNS of patients with multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). However, the underlying mechanism for the axonal damage associated with MS/EAE and its contribution to the clinical symptoms remain unclear. The expression of a fusion protein, named "Wallerian degeneration slow" (Wlds), can protect axons from degeneration, likely through a -nicotinamide adenine dinucleotide (NAD)-dependent mechanism. In this study, we find that, when induced with EAE, Wlds mice showed a modest attenuation of behavioral deficits and axon loss, suggesting that EAE-associated axon damage may occur by a mechanism similar to Wallerian degeneration. Furthermore, nicotinamide (NAm), an NAD biosynthesis precursor, profoundly prevents the degeneration of demyelinated axons and improves the behavioral deficits in EAE models. Finally, we demonstrate that delayed NAm treatment is also beneficial to EAE models, pointing to the therapeutic potential of NAm as a protective agent for EAE and perhaps MS patients.
jimmylegs wrote:heya cob, did anyone say they worked in the same way? did i not just say i couldn't find anything specific about b3 and ms?
Lets not forget we are on an MS board.jimmylegs wrote:vitamin b3 can also be used as an alternative to statins.
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