Hi Dom,TwistedHelix wrote:Now it's my turn to try and interpret one of your posts!
Are you saying that there was a point in our recent past when something changed: something was removed from our systems which up until then had protected us from certain diseases, and the further away we get from that point in history, the more common and aggressive MS becomes? Would I also be right in thinking that, right at this very moment, your fingers are hovering above the keyboard just itching to type the word "helminths"? If so, I can't see anything wrong with that theory, but I also can't see a mechanism which would make things actually deteriorate over time -- you either have worms, or you don't.
Good question and I overcomplicated things. It might have been better if I'd only mentioned that MS "seemed" to become less aggressive the longer a given population is exposed to it and left increasing incidence out of the picture altogether. The reasons? Even though figures being used for any studies we would be reading claim that MS incidence is increasing, other than a few isolated spots in the apallatians parasites have pretty much become extinct in the US in the last 20 years or so and if this "loss of environmental normal conditions" thing has any truth to it, increasing incidence per capita should be leveling off, given that it takes 10-15 years for some of these parasites to die out. In other words, increasing incidence really has no relationship to whether or not MS is getting milder in subsequent generations and I shouldn't have mentioned it.but I also can't see a mechanism which would make things actually deteriorate over time -- you either have worms, or you don't.
Hi Sarah, I see your point but remember that the figures used by researchers involve averages so it would be expected that within those averages remain a good number of very aggressive cases and very mild cases.Just to put a small spanner in the works, as an Anglo-Saxon female who first developed MS at the age of 24. For years it was very benign and I had years of thinking "Oh, its not that bad, I can cope with this." But relapses then became more frequent with less full recovery in between, then in 2001 it suddenly became very aggressive. So aggressive that I shouldn't be here now.
Hi Dom,TwistedHelix wrote:So MS gets less aggressive over time? Do you think our bodies are rebalancing to find a new homeostasis with each passing generation: absorbing and compensating for the loss of something protective? As you said, that would be a remarkably quick adaptation--too quick for evolution--but it would be possible if this system contained a wide margin of natural fluctuation,
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