Hi Dom,TwistedHelix wrote:The different rates of MS in men and women has always seemed to me to contain important clues about the origin of the disease. That ratio has changed dramatically over the years, and the difference has become even more pronounced, so maybe the clues might become a little bit more obvious:
Several epidemiological investigations conducted in Sardinia,insular Italy, indicate that the strong selective pressure of malaria along the centuries may have concurred to the elevated genetic MS-risk in this region. To test such hypothesis in an experimental setting, we have compared the immune response to P. falciparum (the causative agent of malaria) in Sardinian MS patients relative to their ethnic healthy controls and control MS patients of different ethnicity. To this purpose, the P. falciparum-driven peripheral mononuclear cell proliferation, the production of pro-inflammatory cytokines of the innate immunity such as TNF-α, IL-6 and IL-12 and the ability to inhibit the parasite growth have been tested in relation to HLA-DR alleles and TNF promoter polymorphisms known of being associated to MS.
We found that P. falciparum-induced proliferation, cytokine production and parasite killing are significantly augmented in Sardinian MS patients as compared to controls (p < 0.01). Additionally, a correlation is found with genes associated to Sardinian MS, namely the TNF− 376A promoter polymorphism and the class II HLA-DRB1low asterisk0405 allele. In conclusion, we have found evidences that some genetic traits formerly selected to confer a protective responses to P. falciparum now partially contribute to the elevated MS susceptibility amongst Sardinians.
Hi gwa,gwa wrote:Another theory is that women are becoming better educated and are less willing to have doctors classify their symptoms as neurotic, hypochondria, stress or anxiety related.
Maybe we are just getting properly diagnosed now.
doctors classify their symptoms as neurotic, hypochondria, stress or anxiety related.
Maybe we are just getting properly diagnosed now
I'll have to go back and read what I said but without a doubt I DO think that sex bias is related to MS.TwistedHelix wrote:
As you know, I'm already pretty convinced by your ideas and research about environmental parasites, but what is it that's convinced you that the sex bias is not related to MS?
OK, the best I can explain it is that I'm convinced that the loss of "evolutionary normal conditions", which includes the loss of human parasites, directly led to the incidence of "autoimmune diseases". Unlike any other theory, in six years of obsessing with this I've yet to come across any square pegs I've had to force into round holes BUT I've also never been able to use this theory to answer the reasons for sex bias or to explain why incidence seems to continue to increase despite the fact that internal human parasites have, for the most part, been extinct in the continental US since the 1960's or 1970's. To some degree it seems we're no longer talking about the generation of humans which was alive when the parasites became extinct but possibly several generations later. I can understand the continuing succeptibility to autoimmune disease, but not increasing incidence.Lyon wrote:I feel comfortable that I've explained to my satisfaction the reason for the incidence of these inflammatory diseases but continue to be at a loss regarding the female sex bias seen in most of them
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