Testosterone study

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Testosterone study

Postby TwistedHelix » Thu May 17, 2007 12:06 pm

Testosterone treatment in multiple sclerosis: a pilot study.Sicotte NL, Giesser BS, Tandon V, Klutch R, Steiner B, Drain AE, Shattuck DW, Hull L, Wang HJ, Elashoff RM, Swerdloff RS, Voskuhl RR.
Author Affiliations: Division of Brain Mapping, Departments of Neurology and Biomathematics, and Laboratory of Neuro Imaging, The David Geffen School of Medicine at UCLA, Los Angeles, Calif;

OBJECTIVE: To study the effect of testosterone supplementation on men with multiple sclerosis (MS). Design, Setting, and PARTICIPANTS: Men are less susceptible to many autoimmune diseases, including MS. Possible causes for this include sex hormones and/or sex chromosome effects. Testosterone treatment ameliorates experimental allergic encephalomyelitis, an animal model of MS, but the effect of testosterone supplementation on men with MS is not known. Therefore, 10 men with relapsing-remitting MS were studied using a crossover design whereby each patient served as his own control. There was a 6-month pretreatment period followed by a 12-month period of daily treatment with 10 g of the gel containing 100 mg of testosterone. MAIN OUTCOME MEASURES: Clinical measures of disability and cognition (the Multiple Sclerosis Functional Composite and the 7/24 Spatial Recall Test) and monthly magnetic resonance imaging measures of enhancing lesion activity and whole brain volumes. RESULTS: One year of treatment with testosterone gel was associated with improvement in cognitive performance (P = .008) and a slowing of brain atrophy (P <.001). There was no significant effect of testosterone treatment on gadolinium-enhancing lesion numbers (P = .31) or volumes (P = .94). Lean body mass (muscle mass) was increased (P = .02). CONCLUSION: These exploratory findings suggest that testosterone treatment is safe and well tolerated and has potential neuroprotective effects in men with relapsing-remitting MS. Trial Information clinicaltrials.gov Identifier: NCT00405353.

PMID: 17502467 [PubMed - in process]
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Postby CureOrBust » Fri May 18, 2007 2:22 am

I was getting really interested when they mentioned disability in the objective, but felt cheated in that it wasnt in the conclusion.
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