I agree that ALL MS research and related theories are quite tentative at this point. However, in the spirit of debate (the only way we really ever learn anything, in my opinion), here are couple of counter-points to your post.
2. Perhaps antibiotics are neuroprotective and that's the reason they work- but I don't buy the idea that the lower immunse response over time. Some of the case examples (out of Vanderbilt, for example) show relatively quick response- that subset can't be explained that way, anyway.
(Because it seems quite possible to me that there are a sub-set of those diagnosed with MS who would have terrific response to antibiotics, yet they are unlikely to ever have them prescribed. As has been pointed out, if any other part of the body showed such a constellation of symptoms with unknown etiology, a bacterium would be suspected and treated in search of response...yet in terms of MS, this does not happen).
Yes, the research has a long way to go. But, frankly, I think there's enough out for this to be a reasonable intervention to TRY. There's also enough research for doctors to stop being gutless and try to help the desperate patients suffering from these symptoms, rather than simply covering their own asses, which is what I observe here in the U.S
As far lowered immune response - have a look at the various articles on pub med and you will see that the antibiotics in this regime are the most potent immune suppressor, furthermore there have been very mixed results in the use of them in the treatment of cPN. Some such as roxithromycin (as in this regime) increase immune reaction within the first 14 days of use and then radically lower it.
But when other researchers tried to confirm Sriram's results, many of them failed. Skepticism has been running high, and in April 2001, the title of a review in Trends in Microbiology bluntly summed up the feeling of many researchers: "Chlamydia pneumoniae and multiple sclerosis; no significant association."
Sriram disputes this finding, noting that other labs used different methods than his and might have missed the bacteria. To resolve the issue, he and the other researchers agreed to conduct a blind test of cerebrospinal fluid from the same set of MS patients and controls. Sriram found Chlamydia in 73% of the people with MS and 23% of those without. The other three labs found no evidence of Chlamydia at all.
At my worst just over a year ago I would have measured 6 - 6.5 on the EDSS scale, but now I am barely 2, this after being progressive for, in all honesty, about three years. This is why I say it is worth trying, never mind lumbar punctures and all that: I have never had one.PMS: 'The likelihood of remission after such an interval [1 year] is low.
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