This Is MS Multiple Sclerosis Community: Knowledge & Support

Welcome to the world's leading forum on Multiple Sclerosis research, support, and knowledge. For over 10 years, This is MS has provided an unbiased community dedicated to Multiple Sclerosis patients, caregivers, and affected loved ones.
It is currently Sat May 25, 2013 9:57 am


All times are UTC - 8 hours [ DST ]




Post new topic Reply to topic  [ 10 posts ] 
Author Message
 Post subject: MS and NO2
PostPosted: Wed Jun 20, 2007 6:06 am 
Offline
Newbie
User avatar

Joined: Tue Jun 19, 2007 3:00 pm
Posts: 7
Does anyone have info on the possible effect of Nitric Oxide supplements on MS?


Top
 Profile  
 
 Post subject:
PostPosted: Thu Jun 21, 2007 5:50 am 
Offline
Family Elder

Joined: Sun Aug 27, 2006 3:00 pm
Posts: 775
Location: Ireland
Hi Kev and welcome
I've only ever heard of Nitric Oxide in a negative sense to MS - implicated in a possible cause of relapses.
Never heard of taking it as a supplement...


Top
 Profile  
 
 Post subject:
PostPosted: Thu Jun 21, 2007 6:20 am 
Offline
Newbie
User avatar

Joined: Tue Jun 19, 2007 3:00 pm
Posts: 7
Thanks for the welcome. I take the NO when I work out in the gym, since it seems to help with recovery.


Top
 Profile  
 
 Post subject:
PostPosted: Thu Jun 21, 2007 7:41 am 
Offline
Family Elder
User avatar

Joined: Fri Mar 25, 2005 4:00 pm
Posts: 599
Location: Northamptonshire, England.
Hello Kev, and welcome to the gang!
As WW says, NO has historically been implicated in the process of damage during MS activity. If you take a look at the link below you'll see the consensus of opinion, (even though they are all from 2003, I don't think the position has changed):
http://lansbury.bwh.harvard.edu/ms_and_nitric_oxide.htm

Peroxynitrite is a derivative of NO and directly causes damage. It is scavenged by uric acid, and uric acid is known to be generally low in MS sufferers. I take Inosine as a supplement to increase my uric acid levels, and although you can find Inosine as an ingredient in some body building preparations, I'm not sure it will be enough to counteract any additional NO you may be taking,

_________________
Dom


Top
 Profile  
 
 Post subject:
PostPosted: Thu Jun 21, 2007 9:22 am 
Offline
Newbie
User avatar

Joined: Tue Jun 19, 2007 3:00 pm
Posts: 7
Thanks to all. I'll never take the stuff again!


Top
 Profile  
 
 Post subject:
PostPosted: Thu Jun 21, 2007 3:41 pm 
Offline
Volunteer Moderator

Joined: Sat Mar 11, 2006 4:00 pm
Posts: 7632
yea sounds like a great idea, kev. i even have a note to file with my dentist too, no laughing gas please and thank you!


Top
 Profile  
 
 Post subject:
PostPosted: Fri Jun 22, 2007 3:17 am 
Offline
Family Elder

Joined: Sun Aug 27, 2006 3:00 pm
Posts: 775
Location: Ireland
Hey Kev
just thought of something else that u might find interesting.

I take alpha-lipoic acid and n-acetyl-n-carnitine, both of which are antioxidants and have shown some signs of helping fatigue and ms activity in limited studies - I'm sure one of the info-whizzes on the site will dredge up the references for you! :lol:

I also train regularly and I don't know if these things help at all, or if I'm going through a good phase physically of MS that would have happened anyway, but that's working well for me at the moment.

WW


Top
 Profile  
 
 Post subject: Re: MS and NO
PostPosted: Sun Jun 24, 2007 5:29 pm 
Offline
Volunteer Moderator
User avatar

Joined: Sat Nov 20, 2004 4:00 pm
Posts: 2717
jimmylegs wrote:
yea sounds like a great idea, kev. i even have a note to file with my dentist too, no laughing gas please and thank you!

Laughing gas is nitrous oxide which has a chemical formula of N2O. That's a different molecule from nitric oxide or NO. In addition, NO2 given in the original subject for this thread is the formula for nitrogen dioxide, a toxic reddish brown gas which is a component of photochemical smog (note that NO2 is also the chemical formula for nitrite but this has a different chemical structure in the arrangement of its electrons). Now that we've cleared up that bit of confusion, it may still be a good idea to avoid nitrous oxide as it's listed as an oxidizing agent (that's why it's used in race car engines so that more fuel can be burned).

NHE


Top
 Profile  
 
 Post subject:
PostPosted: Tue Jun 26, 2007 11:10 am 
Offline
Volunteer Moderator

Joined: Sat Mar 11, 2006 4:00 pm
Posts: 7632
haha, thanks for clearing that up NHE :) i've just been trying to stay away from anything with and N or an O. stupid air's been a bit of a stumper so far ;)

nitrous oxide can contribute to b12 deficiency which can cause spinal lesions similar to those seen in ms patients - and i have a long relationship with b12 deficiency so that's why i try to avoid it.


Top
 Profile  
 
 Post subject:
PostPosted: Tue Jun 26, 2007 2:51 pm 
Offline
Volunteer Moderator

Joined: Sat Mar 11, 2006 4:00 pm
Posts: 7632
interesting, was just having a think about magnesium and ran across this:

Quote:
Med Hypotheses. 2001 Feb;56(2):163-70.
The multifaceted and widespread pathology of magnesium deficiency.Johnson S.
sjohnson@qwksilvr.com

Even though Mg is by far the least abundant serum electrolyte, it is extremely important for the metabolism of Ca, K, P, Zn, Cu, Fe, Na, Pb, Cd, HCl, acetylcholine, and nitric oxide (NO), for many enzymes, for the intracellular homeostasis and for activation of thiamine and therefore, for a very wide gamut of crucial body functions. Unfortunately, Mg absorption and elimination depend on a very large number of variables, at least one of which often goes awry, leading to a Mg deficiency that can present with many signs and symptoms. Mg absorption requires plenty of Mg in the diet, Se, parathyroid hormone (PTH) and vitamins B6 and D. Furthermore, it is hindered by excess fat. On the other hand, Mg levels are decreased by excess ethanol, salt, phosphoric acid (sodas) and coffee intake, by profuse sweating, by intense, prolonged stress, by excessive menstruation and vaginal flux, by diuretics and other drugs and by certain parasites (pinworms). The very small probability that all the variables affecting Mg levels will behave favorably, results in a high probability of a gradually intensifying Mg deficiency. It is highly regrettable that the deficiency of such an inexpensive, low-toxicity nutrient result in diseases that cause incalculable suffering and expense throughout the world. The range of pathologies associated with Mg deficiency is staggering: hypertension (cardiovascular disease, kidney and liver damage, etc.), peroxynitrite damage (migraine, multiple sclerosis, glaucoma, Alzheimer's disease, etc.), recurrent bacterial infection due to low levels of nitric oxide in the cavities (sinuses, vagina, middle ear, lungs, throat, etc.), fungal infections due to a depressed immune system, thiamine deactivation (low gastric acid, behavioral disorders, etc.), premenstrual syndrome, Ca deficiency (osteoporosis, hypertension, mood swings, etc.), tooth cavities, hearing loss, diabetes type II, cramps, muscle weakness, impotence (lack of NO), aggression (lack of NO), fibromas, K deficiency (arrhythmia, hypertension, some forms of cancer), Fe accumulation, etc. Finally, because there are so many variables involved in the Mg metabolism, evaluating the effect of Mg in many diseases has frustrated many researchers who have simply tried supplementation with Mg, without undertaking the task of ensuring its absorption and preventing excessive elimination, rendering the study of Mg deficiency much more difficult than for most other nutrients.


Top
 Profile  
 
Display posts from previous:  Sort by  
Post new topic Reply to topic  [ 10 posts ] 

All times are UTC - 8 hours [ DST ]


Who is online

Users browsing this forum: No registered users


You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum

Search for:
Jump to: