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The scientists have shown that a gene called SIRT1 and a plant compound found in red wine called resveratrol can protect against neuron degeneration in a mouse model of Alzheimer's disease and amyotrophic lateral sclerosis.
viper498 wrote:Merlot anyone?
Nanotechnology involves the design, synthesis, and characterization of materials and devices that have a functional organization in at least one dimension on the nanometer (ie, one billionth of a meter) scale. One area in which nanotechnology may have a significant clinical impact in neuroscience is the selective transport and delivery of drugs and other small molecules across the blood brain barrier that cannot cross otherwise. Using a variety of nanoparticles composed of different chemical compositions, different groups are exploring proof-of-concept approaches for the delivery of different antineoplastic drugs, oligonucleotides, genes, and magnetic resonance imaging contrast agents. This review discusses some of the main technical challenges associated with the development of nanotechnologies for delivery across the blood brain barrier and summarizes ongoing work.
if neurotrophins such as BDNF or FGF-2 are coupled to BBB molecular Trojan horses, such as a mAb to the transferrin receptor (TfR), then neuroprotection with intravenous administration of low doses is possible.
On a related note, I remember a few years ago where doctors were being troubled in treating brain tumours because the medication wasn't making it past the BBB. They found that injecting sugars before the medication opened up the BBB, and thereby produced considerably better results.TwistedHelix wrote:...and it may be possible to use these as Trojan horses to ferry useful substances across into the brain
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