Hi to all,
I agree that if you have MS and know that it might be transmitted to the recipient of one of your organs, bone marrow, or blood, you should not donate. That was not my original question.
Is there any clinical evidence as to whether or not someone with MS should be an organ donor, participate in the bone marrow donation program, or donate blood.
I believe one of the questions is -- does the memory white blood cells (WBCs) from a person with MS have the capability of replicating themselves and also the ability to produce MRTCs within the new host.
Question number 2 is -- does the bone marrow from a person with MS produce WBCs that will make MRTCs. It seems that the current theory is that the WBCs get triggered by some disease and then mistake myelin as that disease and start to attack it.
Question number 2 is further complicated by results and theories from the cyclophosphamide trials at Stony Brook. That is, once the people in the trial had there immune system wiped clean, the MRTC producing WBCs did not return. Maybe they just had not yet been re-triggered.
I don't think I am as concerned with organ donation as I am with blood and marrow. There are only about 10 to 20 MRTCs per one million T-cells, so the chance that there are enough of them in a donated organ to cause a problem is slight.
Sooooooooooooooooooo, is there any clinical data that would suggest that a person with MS should not be an organ donor, participate in a bone marrow donation program, or donate blood. In the absence of clinical data either for or against, I guess it is best to error on the side of caution and not donate. I would still ponder organ donation from a risk verses benefit factor.