Antibody Promotes Remyelination

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Antibody Promotes Remyelination

Postby TwistedHelix » Sun Sep 30, 2007 12:56 pm

Preclinical Study Published in Nature Medicine Shows Anti-LINGO-1 Antibody Promotes Remyelination
Suggests Potential Role in the Treatment of Multiple Sclerosis and Other
Demyelinating Diseases

CAMBRIDGE, MASS., September 30 /CNW/ - Biogen Idec (NASDAQ: BIIB) announced today the publication of findings from a preclinical study reporting that the anti-LINGO-1 antibody can promote spinal cord remyelination and axonal integrity, suggesting a potential role as a treatment for multiple sclerosis (MS) and other demyelinating diseases of the central nervous system (CNS). The results are published in the October issue of Nature Medicine, and confirm previously published data that suggested a role for the anti-LINGO-1 antibody in CNS myelin repair.

LINGO-1 appears to act as a molecular switch that controls the ability of
cells in the CNS to produce myelin, the protective cellular sheath surrounding nerve fibers that assists nerves in conducting electrical impulses. When myelin is damaged by autoimmune diseases such as MS, nerve cells lose their ability to send signals to the body. As this damage progresses, these cells may eventually die, contributing to disability. Although MS therapies can slow the progression of this damage, none are able to repair the lost myelin. Biogen Idec scientists had previously discovered that LINGO-1 may act to prevent myelin repair after injury. In the study published today, by blocking LINGO-1, scientists were able to promote myelin repair and improve recovery in an animal model of MS.

"While preliminary, these findings are encouraging and suggest that the
anti-LINGO-1 antibody has the potential to repair some of the damage caused to the CNS. This may be an entirely new approach to treating MS," said Alfred Sandrock, MD, PhD, Senior Vice President, Neurology Research and Development, Biogen Idec. "The anti-LINGO-1 program is a key part of our research and development efforts in MS. We have a diverse pipeline of therapeutic candidates targeting multiple pathways and patient needs with the goal of offering a portfolio of options for people living with this devastating disease."

In the study, functional recovery from demyelination was modeled by
tracking the disease progression of experimental autoimmune encephalomyelitis (EAE), a widely accepted animal model for studying the clinical and pathological features of MS. The anti-LINGO-1 antibody was administered before disease onset and was found to decrease the severity of EAE across all stages of disease progression, when compared to the control treatment group. In a related study, anti-LINGO-1 antibody treatment resulted in significantly reduced EAE symptoms even when it was administered after disease onset.

The study found that functional recovery, as measured by EAE scores,
correlated with improved axonal integrity and axonal remyelination.
Physiological improvements in axonal integrity were revealed by magnetic
resonance DTI imaging. At the cellular level, the production of new myelin
sheaths was revealed by histological staining and electron microscopy.

"This is a very exciting early indication that therapies targeted at
myelin repair within the CNS can have a dramatic effect on behavioral
functional outcome in models of multiple sclerosis, and opens the door for the identification of additional regulators of myelin repair that might be used to enhance functional recovery in patients with MS," said Robert H. Miller, PhD, Principal Investigator, Myelin Repair Foundation and Director of the Center for Translational Neuroscience, Case Western Reserve University.

Anti-LINGO-1 was discovered by Biogen Idec and is one of several programs in the company's industry-leading research and development efforts in MS. In addition to its two marketed products, the company has four programs in clinical development for the treatment of MS.

About Biogen Idec

Biogen Idec creates new standards of care in therapeutic areas with high unmet medical needs. Founded in 1978, Biogen Idec is a global leader in the discovery, development, manufacturing, and commercialization of innovative therapies. Patients in more than 90 countries benefit from Biogen Idec's significant products that address diseases such as lymphoma, multiple sclerosis, and rheumatoid arthritis. For product labeling, press releases and additional information about the company, please visit www.biogenidec.com.

Safe Harbor/Forward-Looking Statements

This press release contains forward-looking statements regarding
anti-LINGO-1 antibody, which is currently in the preclinical stage of drug
development. Drug development involves a high degree of risk. Only a small number of research and development programs result in commercialization of a product. Factors which could cause actual results to differ materially from Biogen Idec's current expectations include the risk that the company may not be able to demonstrate the safety and efficacy of anti-LINGO-1 antibody at each stage of the clinical trial process; technical hurdles relating to the manufacture of anti-LINGO-1 antibody may be encountered; the company may not be able to meet applicable regulatory standards or regulatory authorities may fail to approve anti-LINGO-1 antibody; and the company may encounter other unexpected hurdles. For more detailed information on the risks and uncertainties associated with Biogen Idec's drug development and other
activities, see the periodic and current reports that the company has filed
with the Securities and Exchange Commission. Biogen Idec assumes no obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise.



For further information: MEDIA CONTACTS: Biogen Idec Amy Reilly,
617-914-6524 or INVESTOR CONTACTS: Biogen Idec Eric Hoffman, 617-679-2812
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Postby CureOrBust » Sun Sep 30, 2007 4:39 pm

And it doesn't just appear to be remylinatipon.
LINGO-1 negatively regulates neurite outgrowth and myelination.

http://www.rndsystems.com/pdf/AF3086.pdf

when following this up, i kept on seeing the source as being goats, and storage at -20C and could help but think of Aimspro (and SF1019 to a lesser extent) I wonder...
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Postby CureOrBust » Sun Sep 30, 2007 5:02 pm

found a full article on the topic: http://www.jbc.org/cgi/content/full/281/47/36378

I don't understand how come they are talking about it now when I kept on finding articles on it published in 2004!
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Postby itsjustme » Tue Oct 09, 2007 10:44 am

Hi,

I'm a little slow - too dizzy...

I thought this was BIG news but I don't see too much mentioned about this anti-lingo compound. Is this the same stuff from the Mayo Clinic?
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Postby Lyon » Tue Oct 09, 2007 1:44 pm

Is this the "stuff from the Mayo Clinic" that you were referring to itsjustme? http://www.thisisms.com/ftopict-4532.html
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Postby itsjustme » Tue Oct 09, 2007 3:11 pm

Lyon wrote:Is this the "stuff from the Mayo Clinic" that you were referring to itsjustme? http://www.thisisms.com/ftopict-4532.html


Yes, it looks like the same Antibody lingo-1 being addressed in both announcements.
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Postby Lyon » Tue Oct 09, 2007 4:04 pm

I see what you mean.

I should have stayed out of it but I was wondering what Mayo information you were talking about.

I have to admit that they seem similar but I don't get the impression that they're doing exactly the same thing or are the same antibody.

If it were the same, I think the people at Cambridge would have given Ian the impression that the people at Mayo were attempting to steal their thunder and it didn't seem that way at all.

Then again, I know zip about antibodies :lol:

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Postby Sharon » Wed Oct 10, 2007 12:13 pm

Just to add a note to this discussion: this is from the Myelin Repair Foundation site, Scott Johnson - President

Posted October 1, 2007

LINGO-1 Antibody Promotes Myelin Repair

We are excited by today's announcement from Biogen Idec about the latest findings related to myelin repair. According to a study published in this month's issue of Nature Medicine, researchers at Biogen Idec, the University of Hong Kong and the University of Science and Technology of China have determined in preclinical studies that LINGO-1, a molecule which normally acts to prevent myelination, can be blocked by a LINGO-1 antibody. By blocking LINGO-1 in laboratory animals, scientists were able to promote myelin repair and improve recovery. This announcement supports our own findings in 2005 of several other biological processes that may regulate myelin production and repair in the central nervous system (funded in part by Biogen Idec). We are advancing our research on those targets at this time. Biogen Idec's support of MRF and others interested in myelin repair lends further credibility to our own focus on the repair of myelin and the potential it holds for halting the progress of MS.

--Scott Johnson



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