They want me to go on either rebif or beta seron, depending on what my insurance covers.
My advice has been and will continue to be as follows. Get the doctors' prescribing information for any of the drugs you are considering. Next, get a medical dictionary. I happen to like Stedman's
but there are others (and you can usually find these fairly inexpensively at a used book store or for free at your library, I bought an older used edition for about $7). Next, look up every word in the prescribing information that you're unfamiliar with and write it down. Once you've got a good understanding of the information that's being presented you can make a comparison between the available drugs. This is the path that I followed and, yes, it takes a little bit of effort but I feel it's worth it in the end.
You can read one of my recent comparisons in the following thread.
Note that in a prior post I attached some of the data plots for Avonex while in a later post I attached a data plot for Tysabri (it's on the next page in that thread).
As the above post indicates, I wound up choosing Avonex. One of the factors in making this decision was the lack of injection site reactions which are described as injection site tissue necrosis by the prescribing information for Betaseron. Another factor was the fact that Avonex is raised in mammalian cells and is identical to natural human interferon-beta so it has less tendency to elicit neutralizing antibodies.
Keep in my though that as those data plots illustrate, the current drugs have a limited efficacy. Therefore, you may want to consider using a complementary treatment such as diet, supplements, etc. many of which are discussed in the other forums. Lastly, ask a lot of questions and read references that others have found useful (you may want to take a look through the Reading Nook