OK, I guess. To each, her ownlyndacarol wrote:(You know I can't give up the insulin angle--I have a reputation to uphold!)
Hi Dom,TwistedHelix wrote:I'm sorely tempted to join you with the parasites on the dark side, but I don't want to condemn those poor, defenceless little creatures when I suspect they may have other accomplices like hormones, diet, stress etc..
What we are seeing involves two completely different situations.TwistedHelix wrote:I am very, VERY convinced by the hygiene hypothesis, but there's just one small question mark which you describe exactly: why isn't it too late after the age of about 15?
One thing that has become eminently clear is the inadequacy of the terms "cure" and "disease". They are so vague and all encompassing as to be absolutely worthless in what we would like to use them for. I use the word "cure" about 15 different ways, you and everyone else does and none of us have any way of knowing what the other means when they use it. Considering your above use of the word "cure", I again argue that he was an adult, already experiencing immune dysfunction. He did experience positive results but because of reasons mentioned above, at this point it's unfair to expect the opposite of the cause to be the cure in this case (if "cure" is considered to be a one time treatment.TwistedHelix wrote: I have heard of some adults with chronic asthma experiencing what amounts to a "cure" after exposure to parasites, (remember the guy who walked barefoot through latrines?), but the fix isn't permanent and re–exposure is often necessary
My above arguments have pretty much answered this to the best of my ability. With that said, I think it's a situation involving what I can't help but think of as a "predominant" predisposition. One key factor without which it would be impossible for the disease process to start, and after that other factors come into play. It's important to always realize that the only view we've ever had of MS is AFTER it's started, so we're seeing evidence of all the factors and makes it seem like stopping the disease involves some nightmare situation of having to know and correct multiple different factors, when in reality we only need to reverse the key factor.TwistedHelix wrote: so I just wonder if there's something else during childhood which establishes the immune system change permanently for life, (hormones, diet etc. – all the usual suspects). After all, not every child who lives free of parasites will go on to develop disease, so I'm guessing that there must be some other contributing factor.
The aspect of where the immune system's education is "stored" and what mechanism signals the end of the immune system's adolescent education is interesting, but is something I've never considered before and I can't even speculate, although it's coincidental that you mention the thymus because think in the past, you and I have discussed other reasons to suspect the thymus.TwistedHelix wrote:I am further convinced because the thymus involutes, (atrophies), in response to testosterone, and since this is where T cells mature and some autoreactive cells are deleted, it could partly explain this loss of learning function.
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