caffeine

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caffeine

Postby dignan » Thu Apr 03, 2008 8:28 am

Firstly, stop reading this right now and go make some coffee...ok? now read on...oh, and maybe this has something to do with why statins might help in MS?


Daily caffeine 'protects brain'

The easy way to neutralise cholesterol?

BBC - Coffee may cut the risk of dementia by blocking the damage cholesterol can inflict on the body, research suggests.

The drink has already been linked to a lower risk of Alzheimer's Disease, and a study by a US team for the Journal of Neuroinflammation may explain why.

A vital barrier between the brain and the main blood supply of rabbits fed a fat-rich diet was protected in those given a caffeine supplement.

for the rest of the article:
http://news.bbc.co.uk/2/hi/health/7326839.stm
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Postby DIM » Thu Apr 03, 2008 1:27 pm

Caffeine affects remarkably uric acid levels that need to be as high as possible in every MS patient - of course between normal levels but preferably at the upper limit.
And through various researches this is again and again prooved as uric acid is a peroxinitrite scavenger!
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Postby jimmylegs » Thu Apr 03, 2008 6:06 pm

excellent, i was just looking for an excuse for some 9pm java ;D
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Postby DIM » Fri Apr 04, 2008 9:24 am

jimmylegs wrote:excellent, i was just looking for an excuse for some 9pm java ;D

Jimmy if you refer to my post I mean caffeine reduce uric acid levels which isn't good!
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Postby dignan » Fri Apr 04, 2008 11:18 am

This is really a good example of how tricky it is to figure out what helps and what hurts one's MS. I think maybe you could have it all. If you have your uric acid levels monitored, you can take whatever amount of inosine you need to get your levels in the optimal range while consuming as much caffeine as you want. The caffeine would make you have to take more inosine, but if you can afford it, wouldn't it be better than avoiding caffeine? I don't know the answer, just thinking out loud...
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Postby jimmylegs » Fri Apr 04, 2008 11:41 am

oh dammit DIM, i just had another one too !!!
maybe this is part of the reason why my UA levels are always so "ms-average"
i should get off my caffeinated heinie and find some inosine. in the meantime, i am scarfing down liverwurst so if purines can help, they are busy right now too :)
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Postby Wonderfulworld » Fri Apr 04, 2008 1:53 pm

Jimmylegs just have an apple and your uric acid levels will spike back up again :lol: .
Was surfing aimlessly for "uric acid" + "raises/raised" - as you do - recently and found an article on how apples cause a huge spike in uric acid levels. On the Linus Pauling website. Didn't seem authoritative but I could stand corrected. It just caught my eye...........one for more digging, some other day.
I'm such a nicer person on coffee.(Confirmed by my work colleagues, mother and husband some of whom don't agree with coffee, per se). That's all the excuse I need. :wink:
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Postby jimmylegs » Fri Apr 04, 2008 2:52 pm

hey there :) cool my snacks for the last few days have been organic apple sauce and liverwurst so hopefully i'll be doing ok ww, in spite of my caffeine intake, which i'm sure makes me a nicer person to deal with too hahah :)

i guess with the apples it would be due to the high fructose content?? reading over the wikipedia UA page reminded me of this med hypotheses abstract
http://www.ncbi.nlm.nih.gov/pubmed/10985916?dopt=AbstractPlus
which, in light of my recent experiences, diagnoses, and testing, is quite interesting. but it has nothing to do with caffeine, more to do with mg, zn, b2, and b6!
ps. the wiki UA page citation 30 links to a fructose/uric acid journal ref.. i just put it there myself, but it was not hard to find ;)
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Postby Wonderfulworld » Sat Apr 05, 2008 12:25 pm

Yes you might be right about the fructose causing the UA spike.
That's a fascinating article. What about calcium then - does it work against magnesium or synergistally with it do you know?
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Postby jimmylegs » Sat Apr 05, 2008 1:01 pm

hi ww! when i have more time i have to double check if you refer to the med hypotheses article, or the fructose one.
either way, i am pretty sure calcium and magnesium work together, with vitamin D3, but i need to look at it all more carefully, one more time. i don't have it on the tip of my tongue, but there must be a researched rationale for existing supplement products that include calcium, magnesium, zinc, and vitamin D3 together... i will investigate and post outside the caffeine thread :)
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Postby DIM » Sun Apr 06, 2008 10:23 am

May be not directy related with MS but you can see the connection between each mineral:
http://home.goulburn.net.au/~shack/minerals.htm
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Postby MattB » Mon Apr 07, 2008 6:20 am

What if you're on Copaxone then? The mannitol in the copaxone is believed to temporarily open the blood brain barrier, would the coffee(caffeine) then negate the effects of Copaxone?
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Re: Minerals

Postby NHE » Mon Apr 07, 2008 1:01 pm

DIM wrote:May be not directy related with MS but you can see the connection between each mineral:
http://home.goulburn.net.au/~shack/minerals.htm

I'm not sure why that site mentions cadmium. It's actually considered to be a neurotoxin and potential carcinogen with no known natural biogolical function.

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Postby cheerleader » Tue Apr 08, 2008 12:38 pm

More news on caffeine today...
Regarding AEA in mice (what else is new?)
Mice given equivalent of 6-8 cups of coffee daily do not develop AEA- AND...more importantly, the researchers at Cornell University are looking into the way caffeine molecules block adenosine in the CNS and how that relates to MS-

Dr. Bynoe concludes that these experiments show that CD73 and adenosine receptor signaling are required for the efficient entry of immune cells into the CNS during the initiation and progression of EAE in mice and, quite possibly, during the development of MS in humans.

http://www.sciencedaily.com/releases/20 ... 162405.htm

Triple Espresso, anyone?
AC
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Postby Jaded » Sun Apr 13, 2008 6:31 am

Ah yes please!

Interesting article - thanks cheerleader. I was beginning to wonder whether I needed to kick the coffee habit but I shall stick to it!

8)

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