Dear Mrs G,
I've ask a medical doctor (she has MS, too) yesterday. She told me that Biogen (> Avonex) now even inofficially
claims, that interferon beta is safe even during pregnancy... I would not recommend interferon beta during pregnancy because in the first trimester of pregnancy it appears to be associated with an increased risk for fetal loss and low birth weight according to some publications I found.
There are some publications about (non-planned) pregnancy and interferon beta. I don't have full text access to all the journals (e.g. Neurology) but I can ask someone.
Here is an abstract from
Pregnancy outcomes during treatment with interferon beta-1a in patients with multiple sclerosis. Sandberg-Wollheim M et al.,
Neurology. 2005 Sep 27;65(6):802-6. Epub 2005 Aug 10. Review.
BACKGROUND: Although patients with multiple sclerosis (MS) are advised to stop interferon (IFN) beta-1a therapy before becoming pregnant, some patients become pregnant while on treatment. METHODS: We examined individual patient data from eight clinical trials with IFNbeta-1a. RESULTS: Of 3,361 women in the studies, 69 pregnancies were reported, of which 41 were patients receiving (or who had stopped receiving within 2 weeks prior to conception) IFNbeta-1a (in utero exposure group), 22 were patients who discontinued IFNbeta-1a treatment more than 2 weeks before conception (previous exposure group), and six were patients receiving placebo. The 41 in utero exposure pregnancies resulted in 20 healthy full-term infants, one healthy premature infant, nine induced abortions, eight spontaneous abortions, one fetal death, and one congenital anomaly (hydrocephalus). One patient was lost to follow-up. The 22 previous exposure pregnancies resulted in 20 full-term healthy infants, one healthy premature infant, and one birth-related congenital anomaly (Erb palsy). CONCLUSIONS: The majority (21/31) of pregnancies that had the potential to go to full term produced healthy infants. The rate of spontaneous abortion was higher, but not significantly so,
in the in utero exposure group compared to general population estimates. Until more exposure data become available, patients remain advised to stop IFNbeta therapy before becoming pregnant.
Interferon beta babies.Neurology. 2005 Sep 27;65(6):788-9.
So if I would like to get pregnant (still no man around
), I would go on with Rebif until the test is positive and than stop.
I have no idea about that fertility treatment for polycystic ovaries, but I wish you all the best - for your weight loss and the treatment!