jimmylegs wrote:the water at my work has UV tertiary treatment not chlorine. region-wide organization, many locations, and the water hasn't killed us yet!
Lyon wrote:I probably should have mentioned earlier that I heard from Dr Fleming on August 8th and he said that they were going to be screening MS patients for the HINT (helminth) trial that week, with the intention of treating 5 patients with T suis ova for three months and measure brain MRI changes (= part 1, safety and preliminary immunoassays). Then in 2009 the intention is to check MRI changes in 15 patients during 10 months of T suis ova treatment (= part 2, preliminary efficacy).
Hi Cece, I haven't wanted to seem nosy by out and out asking him but early on he had said that he wouldn't waste the money on phase II if phase 1 didn't seem promising and he did go on to phase II.Cece wrote: Has there been any information on how the trial is going? It's interesting, to say the least.
Lyon wrote:Hi Cece, I haven't wanted to seem nosy by out and out asking him but early on he had said that he wouldn't waste the money on phase II if phase 1 didn't seem promising and he did go on to phase II.Cece wrote: Has there been any information on how the trial is going? It's interesting, to say the least.
I find it interesting that swine whipworm ova seem to be easing symptoms when you consider that the whole idea behind this is that the helminths which shared evolutionary history with humans are masters of the human immune system, as evidenced by the fact that they survive very comfortably in us despite the purpose of the Human immun system which is to kill eliminate foreign bodies.
Swine whipworms aren't masters of our immune system and in fact are noticed and killed by our immune within several weeks time, yet if the symptom improvements prove real those swine whipworms are doing something right.
Right, both types of hookworms evolved with humans and the whipworms they are selling are actually Trichuris trichiura, the human whipworm rather than the swine whipworm, Trichuris suis, which the FDA begrudgingly allows to be used for US clinical trials.mrbarlow wrote: Autoimmune therapy's garauntee whipworm infection for 18 months. Hookworm for 3 years
Dr. John Fleming, a neurology professor at the University of Wisconsin School of Medicine and Public Health, said his first-round trial of the substance in 2009 showed promising clinical, immunological, and MRI results. Participants reported no significant side effects. http://tinyurl.com/3y4vbxl
As of August 2010, the Phase II study, "Helminth-induced Immunomodulation Therapy (HINT)," was recruiting 20 individuals with RRMS at the University of Wisconsin in Madison and the Marshfield Clinic. Participants will receive a dose of 2,500 ova (tiny eggs) in liquid form every two weeks. After this liquid is ingested, the eggs hatch and grow to the size of an eyelash within the digestive tract, but once in the large intestine, the body's immune system kills the larvae. The primary outcome measure is MS activity, as judged by the number of new gadolinium-enhancing lesions on serial MRI scans. The study is estimated to be completed in March 2011.
“We look at it
like using live yeast
cultures in yogurt,”
said Dr. Fleming.
“The idea is to use
helminth eggs as a
probiotic, in other
words, a live agent
that may provide a
health benefit to patients.”
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