"Exercise pill" AICAR

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"Exercise pill" AICAR

Postby lyndacarol » Sat Aug 02, 2008 12:55 pm

No direct relationship to MS, but, given my fascination with insulin, I found this sentence in the CNN article interesting:
AICAR stimulates muscles to remove sugar from the blood, noted Laurie Goodyear of the Joslin Diabetes Center in Boston.


from 'Exercise pill' burns fat--if you're a mouse

http://www.cnn.com/2008/TECH/science/07/31/exercise.pill.ap/index.html

You may find this abstract to have a little more info:
Friday, August 01, 2008
Cell Article on Effects of "Exercise Pill" on Mice
Cell has a fascinating early online publication on a pill that mimics the benefits of exercise in mice here. The title is "AMPK and PPARδ Agonists Are Exercise Mimetics".

Here is the abstract:

The benefits of endurance exercise on general health make it desirable to identify orally active agents that would mimic or potentiate the effects of exercise to treat metabolic diseases. Although certain natural compounds, such as reseveratrol, have endurance-enhancing activities, their exact metabolic targets remain elusive. We therefore tested the effect of pathway-specific drugs on endurance capacities of mice in a treadmill running test. We found that PPARβ/δ agonist and exercise training synergistically increase oxidative myofibers and running endurance in adult mice. Because training activates AMPK and PGC1α, we then tested whether the orally active AMPK agonist AICAR might be sufficient to overcome the exercise requirement. Unexpectedly, even in sedentary mice, 4 weeks of AICAR treatment alone induced metabolic genes and enhanced running endurance by 44%. These results demonstrate that AMPK-PPARδ pathway can be targeted by orally active drugs to enhance training adaptation or even to increase endurance without exercise.


http://www.cell.com/content/article/abstract?uid=PIIS0092867408008386

Exercise seems often to improve MS symptoms. Could something here be the mechanism?

This interests me because my insulin level is chronically elevated (moderately so); I believe the insulin is damaging my blood vessels and results in the pain in my legs and feet, as well as the swelling (edema) in those extremities (and possibly my unexplained bruising);I have no dietary source of glucose, I am still searching for the stimulus to my pancreas that accounts for the insulin level.

I do appreciate this place to air my musings.
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lyndacarol
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Postby gwa » Sat Aug 02, 2008 3:17 pm

lc,

You told me once that you ate a bowl of blueberries. That has a lot of carbs in it, so if you are eating even berries frequently, you are getting insulin production.

It is pretty difficult to not eat insulin producing foods. Even protein will product insulin if you eat too much of it.

gwa
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Blueberries

Postby lyndacarol » Sat Aug 02, 2008 4:57 pm

GWA--Thanks for your input. I do know there are some carbs in foods (even protein), but I guess I thought I could get away with an occasional bowl of blueberries without sugar--you wrote, "...a bowl of blueberries. That has a lot of carbs in it." (Drat! I had a bowlful for lunch today! I guess it will be my last!); it seems that I am very sensitive to carbs.

I have suspicion of another source, too. When I get more info on it, I'll share my findings with you.

For now, it's salmon for suppertime.
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