Dramtic decrease in EDSS with Liver Transplant ? Why ?

If it's on your mind and it has to do with multiple sclerosis in any way, post it here.

Postby Lyon » Sat Aug 30, 2008 11:22 pm

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Postby viper498 » Sun Aug 31, 2008 5:57 am

Bob,

I don't care what Ian says about you, you are the man! Thank you for the hook-up!

I still think you and I need to plan a trip to England and visit Ian unexpectedly, wouldn't that be fun?

Brock
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Postby Lyon » Sun Aug 31, 2008 7:02 am

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Postby viper498 » Sun Aug 31, 2008 7:29 am

I'm on it!
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Postby viper498 » Sun Aug 31, 2008 7:48 am

What if there is some sort of viral or bacterial infiltration of the liver that creates some soft of MS like syndrome?

What really strikes me is the fact that I have had elevated liver enzymes for a while, before I ever took Ifn-b. It came up in a blood test a long time ago when I had severe abdominal pain. They thought I might have hepatitis, but it turned out that I didn't. I remember the ultrasound of my liver then and it was nice and smooth.

Then, when I was in the hospital with my first real relapse, they mixed up some paper work and had another ultrasound of my liver done. I thought that was strange. But, it turned out that now I have a fatty liver. I saw it in that image then as well and it was rough looking and pitted, it didn't look smooth like it did before.

After that while i was still in the hostpital, they checked my hepatic levels again and all was fine. A year after that, they checked again and enzymes were once again elevated.

Anyway, just thinking out loud.

Brock
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Postby whyRwehere » Sun Aug 31, 2008 8:16 am

Brock if you don't mind me asking, what are your diet and drinking habits like? Anything that might affect your liver function?
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Postby viper498 » Sun Aug 31, 2008 9:40 am

I eat fairly healthy, and don't drink alchohol very often at all. I don't smoke, never have. I don't exercise as much as I should, and probably don't drink as much water as I should either.

before I was diagnosed with MS though, I did drink A LOT of diet soda. I hardly drink any now, but I do have it from time to time.

I hope that answers your questions..
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Postby cheerleader » Sun Aug 31, 2008 9:53 am

Hey Brock...
you are not alone. Many MSers have high liver enzymes and fatty liver for no "apparent" reason. I put together a whole thread on this topic, since I became interested in the liver's implication in MS when my husband was dx. He was told by his neuro he drank too much...and he rarely has a glass of wine. His liver enzymes were thru the roof. I knew something was amiss, because he looked jaundiced as well.

Here's the thread...read up and ask any questions you might have-
http://www.thisisms.com/ftopict-5595-liver.html+enzyme
AC
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Postby whyRwehere » Sun Aug 31, 2008 10:10 am

Yes it does Brock(answer my questions). I just was curious whether one could eat well, etc, and still have problems. My husband hasn't had any sort of blood work done for a while, so it's worth looking at.
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Postby viper498 » Sun Aug 31, 2008 10:36 am

Wow thanks for pointing me to that. Very good.

Brock
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Postby CureOrBust » Mon Sep 01, 2008 5:03 am

cheerleader wrote:Many MSers have high liver enzymes and fatty liver for no "apparent" reason.
I understand you only said "many" and not all, but I actually have a "bullet proof" liver. I am on the highest dose of Lipitor, and have tried many other liver toxic medications, but my readings (thankfully) are always with the normal range, or only marginally outside on 1 or two; nothing that has concerned my doc.

By the way, what is the measure for a "fatty liver"?
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Postby gwa » Mon Sep 01, 2008 8:25 am

viper498 wrote:
before I was diagnosed with MS though, I did drink A LOT of diet soda. I hardly drink any now, but I do have it from time to time.



Haven't you posted lately that you don't have any symptoms? If so, maybe your "MS" was really caused by the aspertame in diet sodas. Symptoms go away when a person stops drinking the diet colas and eating diet foods.

Just a thought.

gwa
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Postby cheerleader » Mon Sep 01, 2008 8:43 am

CureOrBust wrote:By the way, what is the measure for a "fatty liver"?


If the liver enzymes are high and do not resolve in a couple of weeks, docs will do an ultrasound or MRI or biopsy. If the liver is inflamed, or has fatty deposits, ya got a fatty liver. Jeff never had the ultrasound, since his enzymes resolved on their own. Congrats on your slim and trim, liver, Cure!
AC
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Postby viper498 » Wed Sep 03, 2008 7:29 am

Well I don't have any symptoms right now, but I'd had relapses in the past even after a 1.5 year of not drinking aspartame. I kind of thought that might be a cause too, until I had the relapse.
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Postby eric593 » Fri Sep 05, 2008 5:05 am

Since interferon use can cause liver failure, I think there are a few more people out there who have also had liver transplants and have MS - I wonder how they're doing. Wouldn't that be a kicker if there are people who actually suffered liver failure BECAUSE of MS treatment and then went on to experience a remission due to liver transplant?

I'd personally think the remissions would be more related to the immunosuppressants since we're now using potent anti-rejection transplant immunosuppressants in the treatment of MS. That just seems to be the more logical connection rather than any change due to the new liver itself.
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