i'd need to see pn's bloodwork in detail over time to see what really might have been going on, to assess the info, and to decide if zinc excess may have ended up causing a mineral imbalance, etc.
vit e has been shown to be protective against a specific consequence of zinc deficiency, but i can't remember that specific consequence, not off the the top of my head at least.
my b12 levels went higher than i've ever seen them after zinc therapy, and there is research to show improved b12 absorption after zinc therapy. i have bloodwork to show much much much better d3 absorption after zinc repletion. not to mention my uric acid levels FINALLY came up after years of trying with diet. so whatever my liver needed to result in optimal uric acid levels, b12 and vit e weren't doing it.
also, after i used the klenner therapy which was so high in b12 and vit e (the wrong vit e form by the way, but you have to give it some slack since it's so old, doesn't even include d3) i had no problem getting my b12 and d3 levels up.. i just happened to notice after zinc repletion that my levels of b12 and d3 jumped way up and with d3 especially, i had to be much more careful not to take too much.
READ ME key info on nutrient targets - www.thisisms.com/ftopict-2489.html
my approach: no meds so far - just nutrient-dense anti-inflammatory whole foods, and supplements where needed
info: www.whfoods.com, www.nutritiondata.com