prednisone

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Postby robbie » Mon Sep 15, 2008 1:59 pm

so a 200lb guy could take roughly how much (40mg)? a day without taper for how long ?
Had ms for over 19 years now.
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Postby Lyon » Mon Sep 15, 2008 2:10 pm

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Postby CureOrBust » Tue Sep 16, 2008 4:16 am

CureOrBust wrote:I have read somewhere the max / therapeutic dose was calculated at 1mg / Kg body mass / day (about 75mg / day for me, in a single dose / day).
I did a search to see if I could find this kinda info, and came across this site which has the dosage for various conditions. The interesting thing is that they had dosage between 120-180mg/day (for asthma in emergency). The dose calc I mentioned is mentioned numerous times down the page (as well as others). I would speak to your doc / GP. Actually, I think my GP also told me this calc.
http://noairtogo.tripod.com/prednisone.htm

CureOrBust wrote:Also, I checked with 2 docs, and they said if I take it at this dose, I do not have to taper if I keep the pulse to less than 7 days (or was it five... 2 days is all I actually do now). This works for me because I don't really notice effects at the lower dose.
Did a search and found people (and "Doctors") which talked of 3 days as their comfort point without a taper. But again, speak with your doc. I am sure the two I asked pegged it about 5 or 7. One of the sites I came to said it was individual to a patient.

I also remembered another side effect I experienced. People talk of "moon face". A friend (no idea i was on prednisone) said I looked like I gained weight, in the face AND for me it looked good (I was on it longer term at the time, and stopped soon after). :oops: If its way past dinner time... http://vasculitis.med.jhu.edu/treatments/prednisone.html

I came to the two days, as I found this was all I needed to stop a relapse in its tracks, through personal trial and error and that I wouldnt need to taper. I came to 75mg based on my weight, the above calculation, the pills come in 25mg, and I found 50mg was not as effective. Again, through personal trial and error.
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Postby CureOrBust » Tue Sep 16, 2008 4:34 am

Lyon wrote:it "seems" that for someone of your body weight to do exactly as he is doing, you would have to do 91mg per day for two days per month??
I would NOT recommend ANYONE to do what I am doing. This is my own little experiment which is not based on any hard evidence. I "derived" it off the idea / study results in the study on the thread http://www.thisisms.com/ftopict-5965.html which EXPLICITLY uses IV steroids, was monitored / controlled by doctors / researchers, was on PPMS and other things which are different to my case. However, I liked the EDSS improvements they achieved. And I cant really say if it is helping or hurting at this early time.
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Postby robbie » Tue Sep 16, 2008 6:13 am

I liked the EDSS improvements they achieved. And I cant really say if it is helping or hurting at this early time

same here cob, my eye is better yesterday but have been feeling better since day two. this drug helps me feel better than i have in years and has always worked for my double vision and then some.
one question i have is my last bout of double vision was 4 years ago and since then till a few days ago but the prednisone fixed it so why does that inflamation of my eye nerves not come back when the prednisone wears off? why can it be so long to come back to my eyes ?
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Postby gwa » Tue Sep 16, 2008 7:14 am

robbie wrote:one question i have is my last bout of double vision was 4 years ago and since then till a few days ago but the prednisone fixed it so why does that inflamation of my eye nerves not come back when the prednisone wears off? why can it be so long to come back to my eyes ?


Because MS is weird.

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Postby robbie » Tue Sep 16, 2008 8:55 am

Multiple Sclerosis

In the treatment of acute exacerbations of multiple sclerosis daily doses of 200 mg of prednisolone for a week followed by 80 mg every other day for 1 month have been shown to be effective. (Dosage range is the same for prednisone and prednisolone.)

thats allot
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Postby Lyon » Tue Sep 16, 2008 9:15 am

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Postby robbie » Tue Sep 16, 2008 10:47 am

but in the long run he might also find that he's paid a very dear price

this would apply to many of the drugs offered.
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Postby CureOrBust » Wed Sep 17, 2008 2:57 am

Steroids have also been found to shut down BBB permeability.

As for a "price to be paid", the 6-8 years or so of miss diagnosis by the medical fraternity has most likely caused more damage. I was also using prednisone a LOT more with the misdiagnosis of CIDP, so now is really not concerning me (not that that means it shouldn't).
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Postby robbie » Wed Sep 17, 2008 6:32 pm

that the quick improvements in symptoms is owed to the elimination? of inflammation and after the inflammation is gone things slow down and maybe remyelinisation, reaxonisation or rerouting of neural pathways is responsible for the continued, but slower improvement that people notice in the years afterwards.

could this be true for any anti-inflamatory, may not be ellimination but dampen it to different degrees anyway?
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Postby Lyon » Wed Sep 17, 2008 7:21 pm

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Postby robbie » Thu Sep 18, 2008 5:48 am

oh i see
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Postby Loobie » Thu Sep 18, 2008 1:12 pm

Had my blood screen and urine test for steroids today. My left leg finally said uncle and it tipped over into the "only can walk about 200 feet in an hour" category. From the Glutes to the knee, I have no strength. I just had to start IC'ing and my ON has been around even when I'm not hot, so my Dr. is starting the 3 day regimen of 'roids tomorrow if the cbc and urine come back and say it is. I'm kind of excited because I just want a break from going down the slide. I hope it works for me. Any time would be a blessing.
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Postby robbie » Thu Sep 18, 2008 2:01 pm

I hope it works for me. Any time would be a blessing.

it will lew, it might be short but sweet.
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