Amitriptyline wearing off after only 6 wks....?

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Amitriptyline wearing off after only 6 wks....?

Postby Wonderfulworld » Sat Oct 11, 2008 11:13 am

Hi all
had a nasty relapse about 7 weeks ago. Severe fatigue for 3 weeks, and a huge increase in neurological pain - you know the crawling, itching, pricking, nagging, gnawing horrible pain. It was all down my right side - just my right side - and I had twitching too so I wasn't sleeping.

The neurology clinic's nurse sent me a script for very low dose Amitriptyline (I think it's called Elavil in some parts of the world). It worked an absolute treat. All the pain and twitching went after about 3 days on it. It was just heaven to get a break from that awful pain. I was more dopey in the mornings and a bit of constipation but a small price to pay.

Now the pain and twitching is starting to creep back again even though I haven't stopped or changed the dose (25mg).

Has anyone else had this experience? Does Amitriptyline wear off? Do you become immune to each dose over time?
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Postby CureOrBust » Sat Oct 11, 2008 4:17 pm

I have never tried Amitriptyline or know anything about it, but I do have pins and needles / prickly feeling in my feet. i notice when i take Provigil (100mg x 2) by the end of the day the pins and needles seem slightly less prominent, and this continues onto the next day regardless if i take another dose. This is anecdotal, but i thought i might share.
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Postby Toyoterry » Sun Oct 12, 2008 3:27 pm

I also take a small dose of Amytriptiline along with Lyrica. Together they seem to work for my neuropathic pain. This isn't always the case because there are days when nothing seems to work.
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Postby Wonderfulworld » Mon Oct 13, 2008 1:24 am

Thanks Cure, that's interesting about Provigil. I have never tried it - I did try Symmetral in the past though, it seems to work on fatigue too.

Terry perhaps it was just one of those days....I had a few days when all the pain came back but now it's back to "normal" levels again. I am hoping it will stay as it is now.
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