Hi Lyndacarol, I must confess to not knowing much at all about the insulin connection with damage to the endothelium. What I do know is that endothelin 1, a signalling protein, which causes vasoconstriction is massively overexpressed in MS patients and that if you take salvia which inhibits this you get a complete change in MS symptoms!! It seems like quite a few of us have an inexplicable tendency to bruise yet tend to have low blood pressure. Maybe the blood is so thick it doesn't move at all!! Here are some interesting bits and pieces on blood flow:
1: Eur J Neurol. 2008 Jul;15(7):725-9. Epub 2008 May 24. Linkslink
Changing cerebral blood flow velocity detected by transcranial Doppler ultrasound during head up tilt in patients with multiple sclerosis.Gonul M, Asil T, Balci K, Celik Y, Turgut N, Uzunca I.
Erzurum Numune Hospital, Clinics of Neurology, Erzurum, Turkey.
BACKGROUND AND PURPOSE: Multiple sclerosis (MS) is a chronic inflammatory disease of central nervous system. We aimed to investigate the cerebral blood flow velocity (CBFV) changes in MS by transcranial Doppler. METHODS: Twenty patients with MS, 20 age-matched healthy controls were included in the study. In both groups, blood flow velocities (BFVs) of middle cerebral arteries (MCAs) were evaluated. The changes of blood pressure, heart rate along with the changes in BFV of MCA were recorded after the patients were raised to upright position. RESULTS: In both groups, upon raising the tilt table to the upright position, the mean CBFV values were found to be lower in comparison with the recorded baseline values (P values <0.05). The decline in the mean CBFV values was more significant in patients with MS (P = 0.01). CONCLUSION: Our study showed upon raise of the tilt table, the mean BFVs decreased more in MS patients than control group with a more prominent change in the subgroup of MS patients with expanded disability scale scores > or =2. By use of transcranial Doppler ultrasound, it may be possible to evaluate BFV changes in patients with MS.
PMID: 18505409 [PubMed - indexed for MEDLINE]
1: Med Hypotheses. 2008;70(6):1112-7. Epub 2008 Feb 20. Links
Raised venous pressure as a factor in multiple sclerosis.Talbert DG.
Institute of Reproductive and Developmental Biology, Imperial College School of Medicine, Du Cane Road, London W12 ONN, United Kingdom. firstname.lastname@example.org
It is hypothesised that the inflammatory condition seen in MS and the progressive myelopathy that is being successfully halted by obliteration of dural arteriovenous fistulas (DAVFs), may actually be two sides of the same coin. Excessive venous hypertension can stretch vein walls sufficiently to separate the tight junctions between endothelial cells forming the blood-brain-barrier (BBB). Colloids, etc., but not necessarily erythrocytes, could then pass through the exposed porous basement membranes. The resulting changes in osmotic pressure, etc. would disrupt the axon and dendrite internal transport systems, leading to their disintegration. The normal inflammatory processes which would follow, might be indistinguishable from those associated with autoimmune disease. Ascending progressive myelopathy and disablement are associated with an intracranial DAVF when its outflow enters the spinal venous system and descends past the cervical region. This can be arrested, and some degree of recovery produced, if the DAVF can be successfully eliminated or blocked. However, if the DAVF outflow is entirely into the spine, intracranial venous pressure may be normal and so there is nothing to alert the clinician to the presence of an intracranial DAVF. It is suggested that where spinal MS has been diagnosed from clinical observations, patients should be referred for angiological investigation to search for DAVFs within the head to identify any treatable subjects.
PMID: 18079069 [PubMed - indexed for MEDLINE]
1: Clin Neurophysiol. 2004 Jun;115(6):1473-8. Links
Cardiovascular autonomic dysfunction correlates with brain MRI lesion load in MS.Saari A, Tolonen U, Pääkkö E, Suominen K, Pyhtinen J, Sotaniemi K, Myllylä V.
Department of Neurology, Oulu University Hospital, P.O. Box 25, 90029 OYS, Oulu, Finland. email@example.com
OBJECTIVE: The aim of the present study was to investigate the cardiovascular autonomic control in clinically definite multiple sclerosis (MS) patients with a standardised battery of cardiovascular tests and to correlate these findings with the brain magnetic resonance imaging (MRI) lesion load. METHODS: Fifty-one patients with MS and 50 healthy controls were studied. Brain MRI was performed in all patients showing typical MS lesions. The cardiovascular tests were carried out using a standardised battery. RESULTS: Heart rate (HR) responses to deep breathing (P < 0.05) and tilt table testing (P < 0.001) were significantly decreased in MS patients when compared to those of the controls. Blood pressure (BP) responses in the tilt table test were also impaired in MS patients (diastolic P < 0.001, systolic P < 0.05). Of the different brain areas investigated the total volume of the midbrain MRI lesions (P < 0.05) was the one most clearly associated with the impaired BP responses. CONCLUSIONS: MS results in both reduced HR variation and decreased BP reactions indicating disturbed cardiovascular regulation. In particular, the midbrain lesions found in MS are associated with cardiovascular dysfunction.
PMID: 15134718 [PubMed - indexed for MEDLINE]
1: Med Hypotheses. 1986 Oct;21(2):141-8. Linkslink
Damaging venous reflux into the skull or spine: relevance to multiple sclerosis.Schelling F.
Unequal propagation of central venous excess pressure into the different cerebral and spinal venous drainage systems is the rule rather than the exception. The intensity of the forces thus to be exerted on vulnerable cerebrospinal structures by the resulting pressure-gradients in the craniovertebral space is unknown. There is a need to consider the various conditions which may cause individual proneness to heavier reflux into particular cerebral as well as epi- and subdural spinal venous compartments. An attempt is made to indicate eventual consequences of excessive retrograde dilatation especially of internal cerebral veins. The importance of elucidating the neuropathological and clinical implications of undue reflux into the skull or spine is deduced from the probability of relations between localized backflow into the craniovertebral space and unexplicated cerebrospinal diseases. In this regard the features of multiple sclerosis are discussed.
PMID: 3641027 [PubMed - indexed for MEDLINE]
If we all generally have low cerebral blood pressure, perhaps as a result of problems in the renin-angiotensin system ie the kidney/heart, then the veins and capillaries might try to overcompensate by vasoconstricting. This might cause a sort of venous hypertension which from time to time becomes too much and then bursts allowing blood and inflammation into the CNS. Howzat as a theory?!!!
How many people have had kidney infections? My mother had several debilitating attacks on her kidney. I was hospitalized for 5 days with one.
Anyone else have kidney infections/problems?