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If it's like the alemtuzamab trials then you take the Avonex once a week instead of the infusion. Your trial doctor will be blinded to what you get and your not to tell him/her. It won't be double blinded because you'll know what you you're taking.
From what I've read about it, it is a "fully humanized" version of Rituximab. I could be so wrong, but the blurbs I've read about it tout that it is humanized while Rituxan is a synthesized MAB. And since they are talking about Rituxan in the comparison, I just assumed that it is supposed to have the same mechanism of action.
You are correct. Apparently there is a mouse protiene in rituxan that the immune system eventualy creates antibodies against rendering the drug ineffective. This is the same drug as rituxan using a synthetic protien that is more human like.