If it's any comfort, EVERYONE else's brain is looping.mommasan wrote:Not directed at anyone in particular. Just fishing for ideas to help me develop a theory that can stop my brain from looping.
Evidently you have but I've never heard that childhood MS is almost exclusively RR. I don't know what you mean by "Is it just plasticity?"mommasan wrote:Why, when children get MS, it is almost exclusively RR? Is it just plasticity?
First, information based on such small numbers as familial clusters is of no real value over and above being interesting....brain candy.mommasan wrote:Why with familial clusters, those who get it at an older age can be PPMS while their kids who get it earlier can be RR- Alan Osmond and his son David are an example of this.
Despite what some people think and what I have to honor as "alternative" opinions, there is no logical reason to think that MS doesn't involve the immune system. At this point the ball is the hands of others to prove that the immune system isn't involved.mommasan wrote:If it is not related to the immune system in some way, how does Revimmune work?
I don't know what that means.mommasan wrote:Can MS be cohesively related to the cancer model of initiation-promotion.
It's been a while and, right or wrong, after reading about that situation I remember coming to the conclusion that the intense heat of the sun exacerbated her symptoms to the point that she couldn't save herself and likely died of heat stroke or something similar.mommasan wrote: I recall the case of the woman with RR who died of MS after falling asleep sunbathing- not immunological, but the extreme stress of sunbathing was perhaps the promotor. Perhaps there can be many non-immunologically related promotors but the initial process is immune related?
mommasan wrote:I am going to try to get my thoughts together and hopefully not be writing out of the other end.
Why, when children get MS, it is almost exclusively RR? Is it just plasticity?
Why with familial clusters, those who get it at an older age can be PPMS while their kids who get it earlier can be RR- Alan Osmond and his son David are an example of this.
If it is not related to the immune system in some way, how does Revimmune work?
We prospectively studied the alterations of coagulation during adjuvant CNF (Cyclophosphamide, Novantrone -Mitoxantrone, 5-Fluorouracil) chemotherapy in patients with stage II breast cancer. In 50 consecutive stage II breast cancer patients (pre-peri-postmenopausal), and 50 controls,serial coagulation parameters including prothrombin time (P.T.), partial thromboplastin time (P.T.T.), fibrinogen, fibrinogen/ fibrin degradation products (F.D.P.), protein C. protein S, antithrombin III (AT-III) and platelet count were performed.
Fibrinogen, plasma protein C, protein S and AT-III were significantly decreased during chemotherapy.
We have described a 25-year-old woman with recurrent cerebral thrombosis associated with very high levels of antibodies against phospholipids. Antinuclear antibodies and clinical features of a defined connective tissue disease were absent. Treatment with plasmapheresis, prednisone, intravenous cyclophosphamide, and warfarin was accompanied by disappearance from the serum of the lupus anticoagulant and the biologic false-positive test for syphilis; IgG anticardiolipin antibodies persisted, however, and the patient had a second cerebral thrombosis. Clinical improvement ultimately occurred after the dosage of cyclophosphamide was optimized and the level of IgG anticardiolipin antibody decreased to a level lower than any that has been previously associated with thrombotic complications.
As you know, there is a TON of information out there, not all the same, but I've not read that particular distinction.mommasan wrote:Though, and I am sure you have explained this already, in PPMS (I'm sure I am wrong here) isn't it common not to see evidence of demyleinated plaques seen RRMS?
As always I can only say it like I see it but that's a great way to describe how I see MS and considering the complete lack of conclusive proof I like to think that I keep logic on my side.mommasan wrote: What I meant by initiator promotor is that maybe MS is just one disease. Some event (infections- bacterial, viral, etc. + genetic predisposition starts the process) and any number of things stress, hormones, severe oxidative load or the same viruses or bacteria that initiated the immunological process, promote it in different ways in different people.
Hi AC,cheerleader wrote:If it is not related to the immune system in some way, how does Revimmune work?
Since I am vascular girl, I've wrestled with this question. Cytoxin and cyclophoshamide affect coagulation...here's a couple of studies.
Hi AC,cheerleader wrote: And, of course, getting rid of errant t and b cells in the CNS will certainly curtail destruction, at least temporarily...but it hasn't "cured" MS.
Of course the bottom line is that in this area no conclusive evidence exists either way, neither or us can win this one but common sense leans toward a continued acceptance of what most people have always found obvious....that "healthy" habits can be beneficial without actually directly modifying or "reversing" a disease process. If that weren't true it doesn't seem that the concept of "healthy" could have developed among well people in the first place.....in other words, well people don't have to modify a disease process but they can feel better and be demonstrably "healthier" by utilizing "healthy" habits.cheerleader wrote:And if MS is purely immune, than why does the Swank/best bet diet, meditation, lack of stress, breastfeeding, antioxidants, exercise, LDN,(and lots of other hypotension-creating measures) help so many to acheive remission?
cheerleader wrote:Some treatments achieve remission for awhile, some stop inflammation, and there have been a few folks apparently "cured" by stem cell therapies and certain drugs- but then it doesn't work for everyone. Why?
although I find it a little curious that you include the need to be 100% effective 100% of the time.....but the only "correct" answer is each of our opinions!cheerleader wrote:stop MS disease progression and continued axonal damage
Over the years I've thought about that one a lot....in fact I've dwelled on it and I think you're right. Through the years we've had medical advances....big ones, but if someone rigidly adheres to the definition of "cure" as being elimination or reversal of the original cause, "cures" are almost unheard of. The vitamin deficiency diseases.....and I'm not sure that we could even consider mending broken bones as being cured when you consider that we mend them but we don't reverse or eliminate the original cause.cheerleader wrote:We don't have a cure for cancer, MS or the common cold. We have treatments.
I haven't had enough time to think about it so not to concede anything just yet, but now that you mention it, AT LEAST most any external parasite which drinks our blood utilizes natural anti-coagulants and that is just one of the benefits of the medical leeches Detlev Goj's earlier start up company sold before he started Ovamed and started selling the T suis/swine whipworm.cheerleader wrote:back to your thread, because I believe you have something here! The hookworm is noted for its serum iron-depleting and anticoagulative properties!
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