I was diagnosed in 2003 - my MRI showed lesions but none were enhanced or active and there was no inflammation. For that reason, I decided to not go on any of the CRAB drugs. My yearly MRI scans have not changed since 2003. I started LDN in May of 2008 and I just had my 2009 MRI - everything is still stable.
How can the experts explain people who never had lesions on MRI, but have undeniable MS symptoms for decades? Or who worsen over time in symptoms, but never in MRI and lesion status?I am starting to think MRI's don't mean a whole heck of a lot.
if sharon went on one of the crabs right away like the doctors want you to would they say the 6 years of her ms being stable is because of the crab of choice or is it just her paticular ms.
7T MR provides sophisticated imaging capabilities by virtue of increased signal intensity and susceptibility effects, the fundamental quantities underlying image resolution and contrast, respectively. Our findings established that approximately half of total MS lesions in our two patients are small with well-defined central veins, and that these diffuse, subtle signal abnormalities may correspond to early vascular changes. This represents the first time that such subtle vascular inflammatory abnormalities have been demonstrated in vivo. Improved detection of these lesions in the early stage of development on 7T MRI will have substantial ramifications on future diagnosis, monitoring, and therapeutic response in MS. Therefore, utilizing ultra-high-field MRI for precise characterization of microvascular abnormalities in early MS lesion development may allow for immediate
pharmacologic intervention directed at these initial changes.
Multiple sclerosis (MS) lesions have been linked to venous abnormality, although the derivation of these lesions from the vasculature has been difficult to assess in vivo (1,2). Ultra-high-field (e.g. 7T) MR has provided increased visibility of venous vasculature by taking advantage of markedly increased intrinsic intensity and susceptibility contrast (3). We report findings acquired at 7T MR in two MS patients, and demonstrate enhanced detection of unique microvascular abnormalities in MS.
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