sodium channel blockers for SPMS

If it's on your mind and it has to do with multiple sclerosis in any way, post it here.

Postby cheerleader » Mon Mar 02, 2009 8:25 pm

The abstract you've linked to is for axonal and neuronal damage in MS but I didn't see any sodium channel blockers mentioned. I found a complete paper below which explains the theory.

Sodium channel blockers are used for heart arythmia and atrial fibrillation. They can also block neuropathic pain. Sodium channel blockers work on nitric oxide - an imbalance in nitric oxide triggers axonal degeneration via anoxia (oxygen depletion.) Returning nitric oxide balance with diet, supplements and exercise is the theory behind my endothelial healing paper-
Here's a study relating to MS...

http://brain.oxfordjournals.org/cgi/con ... ll/128/1/5

Studies over the past decade have demonstrated that a sustained sodium influx through voltage-gated sodium channels can trigger reverse sodium–calcium exchange which imports damaging levels of calcium into axons after they are exposed to insults such as anoxia, thereby activating injurious calcium-mediated processes (Stys et al., 1992a). Persistent sodium currents have, in fact, been demonstrated along the trunks of axons within the CNS (Stys et al., 1993) and PNS (Tokuno et al., 2003), and sodium channel blockers have been shown to have a protective effect, preventing axonal degeneration when axons are exposed to anoxia (Stys et al., 1992b). A link to neuroinflammation was provided by Smith and colleagues, who demonstrated that nitric oxide (NO, which is present at high concentrations within the lesions of GBS and multiple sclerosis; see Smith and Lassmann 2002) can, possibly via mitochondrial injury which leads in turn to energy deficiency, trigger axonal degeneration (Smith et al., 2001). These investigators further showed that NO-induced axonal degeneration can be prevented by pharmacological blockade of sodium channels (Kapoor et al., 2003).

AC
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
User avatar
cheerleader
Family Elder
 
Posts: 5033
Joined: Mon Sep 10, 2007 3:00 pm
Location: southern California

Advertisement

Postby cheerleader » Mon Mar 02, 2009 8:32 pm

Here's some more from Twisted Helix (Dom) on sodium channel blockers...
Boy, I really miss him. Seeing his picture reminded me how much.
Anyway, a good function, Kitty, is the "search" section up above. You can look up any term on the forums. It's been a huge resource for me.

http://www.thisisms.com/ftopict-4272-so ... l+blockers

AC
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
User avatar
cheerleader
Family Elder
 
Posts: 5033
Joined: Mon Sep 10, 2007 3:00 pm
Location: southern California

Postby chrishasms » Mon Mar 02, 2009 8:54 pm

What happened to Dom?
chrishasms
Family Elder
 
Posts: 1161
Joined: Thu Sep 14, 2006 3:00 pm

Postby cheerleader » Mon Mar 02, 2009 9:03 pm

Bob checked in on him about a month ago. He's still on the planet, but he had some health stuff going on...it's been tough.
Here's the thread...
http://www.thisisms.com/ftopict-6722-dom.html
AC
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
User avatar
cheerleader
Family Elder
 
Posts: 5033
Joined: Mon Sep 10, 2007 3:00 pm
Location: southern California

Postby dignan » Mon Mar 02, 2009 9:46 pm

OK, follow the bouncing ball:

- lamotrigine (lamictal) is a sodium channel blocker
- lamotrigine just finished a phase 2 trial for progressive MS (trial was in the UK, Muu, one of the members here was in the trial, no results yet)
- a generic version of lamotrigine is sold by Teva in the U.S.
- Teva sponsored the paper that Petakitty linked to
User avatar
dignan
Family Elder
 
Posts: 1608
Joined: Wed Aug 11, 2004 3:00 pm


Return to General Discussion

 


  • Related topics
    Replies
    Views
    Last post

Who is online

Users browsing this forum: No registered users


Contact us | Terms of Service