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Euphoria before attack

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LR1234

Post subject: Euphoria before attack

Posted: Fri Mar 06, 2009 11:09 pm

Family Elder

Joined: Wed Feb 11, 2009 4:00 pm
Posts: 1419
Location: California

Hi

Has anyone noticed that they feel really good and well just before a relapse like a real feeling of euphoria? I have noticed this has happened to me a few times now.
I can't work out if its because I feel well I do more hence bringing on an attack or if it is a biological/chemical thing.

Any ideas?

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Wonderfulworld

Post subject:

Posted: Sat Mar 07, 2009 4:28 am

Family Elder

Joined: Sun Aug 27, 2006 3:00 pm
Posts: 775
Location: Ireland

Hi LR1234
I have also noticed this..It's nearly like I'm hyper for a few days then a HUGE sudden crash in my energy.

Sometimes I feel it building up and if I don't go with the false energy I can avert the relapse a bit, but all you want to do is go wild with all the things you can't normally do.

I wonder what causes it....hmmm.

_________________
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Concussus Resurgo
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RR-MS dx 1998 and Coeliac dx 2003
~~~~~~~~~~~~~~~
Copaxone, Cymbalta. EPO, Fish Oils, Vitamin D3 2000 IU daily, Cal/Mag/Zinc, Multivitamin/mineral, Co-Enzyme Q10, Probiotics, Milk Thistle.

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LR1234

Post subject:

Posted: Sat Mar 07, 2009 4:36 am

Family Elder

Joined: Wed Feb 11, 2009 4:00 pm
Posts: 1419
Location: California

I am glad I am not the only one! I definately get this feeling of being really full of enery and hyper and about 4/5 days later I get that massive crash. I also tried last time to avert it when I recognised the feeling but had no luck. I wonder if it is our immune system becoming active in some way.

L

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sou

Post subject:

Posted: Sat Mar 07, 2009 4:32 pm

Family Elder

Joined: Sat Dec 20, 2008 4:00 pm
Posts: 582
Location: Greece

Hi.

I can't seem to find the study right now, but our body increases the production of beta endorphin during relapse, perhaps attempting to prevent it. It could be that endorphin boost that makes you feel that way.

sou

Edit: I have found the study. Here it is:

http://archneur.ama-assn.org/cgi/reprint/57/8/1178.pdf

Quote:

Conclusions: A reduction of BE levels was present in patients with clinically inactive MS. Treatment with IFN-b seems to induce an increase of this opioid in PBMCs of MS patients. The increase of BE concentration during a clinical relapse may represent a possible control mechanism aimed at counterbalancing the inflammatory phase of the disease.

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Shortest joke: "We may not be able to cure MS but we can manage its symptoms."

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Wonderfulworld

Post subject:

Posted: Sun Mar 08, 2009 1:25 pm

Family Elder

Joined: Sun Aug 27, 2006 3:00 pm
Posts: 775
Location: Ireland

Thanks for posting that sue, that is really fascinating.

Wish my system made more beta endorphins because when they do hit, I can do nearly everything I want to. But just wish I could avoid the relapse that comes with it nearly every time.

:wink:

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LR1234

Post subject:

Posted: Sun Mar 08, 2009 2:06 pm

Family Elder

Joined: Wed Feb 11, 2009 4:00 pm
Posts: 1419
Location: California

Me too!! If we can just work out what we have to do at the point the europhia hits perhaps we can avert the relapse.

Thanks for the info Sou

L x

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CureOrBust

Post subject:

Posted: Sun Mar 08, 2009 6:10 pm

Family Elder

Joined: Wed Jul 27, 2005 3:00 pm
Posts: 2692
Location: Sydney, Australia

Wonderfulworld wrote:

Wish my system made more beta endorphins because when they do hit, I can do nearly everything I want to. But just wish I could avoid the relapse that comes with it nearly every time.

Have either of you tried LDN? this all sounds similar to its method of action.

I do not get the euphoria before an attack, because my trigger before an attack is a cold/flu, so I feel pretty rubbish leading into an attack. And LDN did not appear to work for me personally either.

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Wonderfulworld

Post subject:

Posted: Mon Mar 09, 2009 2:33 am

Family Elder

Joined: Sun Aug 27, 2006 3:00 pm
Posts: 775
Location: Ireland

No Cure I've never tried LDN. Been too much of a sissy to come off DMD's - Rebif then Copaxone - mainly because my MS without DMD is aggressive, and because I've done very well on Copaxone. I would definitely try LDN if I ever have to stop Copaxone.

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CureOrBust

Post subject:

Posted: Mon Mar 09, 2009 4:39 am

Family Elder

Joined: Wed Jul 27, 2005 3:00 pm
Posts: 2692
Location: Sydney, Australia

I don't think LDN and Copaxone are contra-indicatory, so you would not have to stop the Copaxone. Others will know more, and I know some are on this combination already.

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Loobie

Post subject:

Posted: Mon Mar 09, 2009 4:47 am

Family Elder

Joined: Mon Sep 11, 2006 3:00 pm
Posts: 2197
Location: Dayton, Ohio USA

I agree Cure. I think "Chrishasms" is doing that combo.

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DIM

Post subject:

Posted: Mon Mar 09, 2009 5:07 am

Family Elder

Joined: Thu Feb 28, 2008 4:00 pm
Posts: 386
Location: GREECE

As copaxone isn't immunosupressive it doesn't interfere with LDN, they work much better together according to some people that takes them both!

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Wonderfulworld

Post subject:

Posted: Mon Mar 09, 2009 1:43 pm

Family Elder

Joined: Sun Aug 27, 2006 3:00 pm
Posts: 775
Location: Ireland

Thanks DIM, Loobie and Cure, that's one to think about.

I have only heard of one other Irish MS'er taking LDN and it's not available easily here I don't think, might email her to ask about it.

Being a worrier with a PhD in worrying, I would worry that the two would interact in some bizarre way in just me out of all the world. :lol:

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DIM

Post subject:

Posted: Tue Mar 10, 2009 12:53 am

Family Elder

Joined: Thu Feb 28, 2008 4:00 pm
Posts: 386
Location: GREECE

Contact Dr Bob Lawrence, he will prescribe it and arrange the shipping, he is PwPPMS and stable for more than 15 years only with LDN, BBD and supplements, you can find contact info at www.ldnresearchtrust.org:
bob.lawrence@ntlworld.com
Good luck

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LR1234

Post subject:

Posted: Tue Mar 10, 2009 2:29 am

Family Elder

Joined: Wed Feb 11, 2009 4:00 pm
Posts: 1419
Location: California

Thanks I will send him an e-mail

L x

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LR1234

Post subject:

Posted: Thu Apr 23, 2009 3:11 pm

Family Elder

Joined: Wed Feb 11, 2009 4:00 pm
Posts: 1419
Location: California

Just thought I would bump this topic just to see if anyone else feels really good just before a relapse....(or feeling really bad)

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