This Is MS Multiple Sclerosis Community: Knowledge & Support

Not really, but look out for that headline at a tabloid near you. Seriously, this article looks at importance of remyelination in pregnant cats with some kind of disorder. It highlights the importance of remyelination, which I've been wondering about since there seems to be demyelination and a neurodegenerative element to MS.


Study of cat diet leads to key nervous system repair discovery

March 30, 2009 - Scientists studying a mysterious neurological affliction in cats have discovered a surprising ability of the central nervous system to repair itself and restore function.

In a study published today in the Proceedings of the National Academy of Sciences, a team of researchers from the University of Wisconsin-Madison reports that the restoration in cats of myelin — a fatty insulator of nerve fibers that degrades in a host of human central nervous system disorders, the most common of which is multiple sclerosis — can lead to functional recovery.

"The fundamental point of the study is that it proves unequivocally that extensive remyelination can lead to recovery from a severe neurological disorder," says Ian Duncan, the UW-Madison neuroscientist who led the research. "It indicates the profound ability of the central nervous system to repair itself."

for the rest of the article:
http://www.physorg.com/news157654992.html

Digna - Great find...I love cats too they are worth there warm fuzzy attention!

Now if only my cat would remyelinate me! I have enough of them that I would be fixed.

Love this!!

CF

_________________
Holly - Shine On You Crazy Diamond - Pink Floyd

9/3/09 Stanford - Dr Dake - Stent in R-J to unblock Arachnoid Cyst in Sigmoid Sinus. Stent in narrowed L-J. Balloon in narrowing where R & L Jugulars meet.

It is indeed important. However, the study is about cats, which are not closely related to humans. It would be more interesting if it were about monkeys.

If we assume that the human nervous system has the ability to remyelinate, why doesn't it? Is it because the MS process is not halted? If that were the case, Lorenzo Odone's brain (who doesn't have MS at all) should have been remyelinated by now.

sou

_________________
Shortest joke: "We may not be able to cure MS but we can manage its symptoms."

I'm not a cat person -sorry all you cat people
but this is a cool study dignan.



But the human nervous system can remyelinate, sou. I put up the research from Luccinetti at Mayo on the "types of lesions" thread....

http://discoverysedge.mayo.edu/de07-4-n ... cchinetti/

My personal paradigm is that the level of venous insufficiency and blockage correlates to the CNS's ability to remyelinate.
AC

_________________
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS

.

Hi.



I only hope that it is true. But then, adrenoleukodystrophies must have something to do with blocked veins. It is very unlikely. So, why doesn't remyelination of the CNS occur in other conditions?

Actually, it doesn't really occur in any condition. To make myself clear, when I say remyelination, I mean it to a degree that allows a person to function normally. This includes going jogging on a hot day. Ok, I would be happy even if the day were cold or not going jogging at all. But what we see is that spontaneous remyelination is more than inadequate. And, while blocked veins could only make things even worse, I doubt that this is the only reason remyelination fails. I wish I prove wrong!

sou

_________________
Shortest joke: "We may not be able to cure MS but we can manage its symptoms."

Actually, leukodystrophies have an etiology that is known. They are a genetic disease, caused by a defect in which the child's body cannot break down sulfatides or long-chain fatty acids. This eventually leads to the demyelination in the brain white matter.

But still remyelination fails, even if the patient adjusts to a diet that prevents further disease progression.

sou

_________________
Shortest joke: "We may not be able to cure MS but we can manage its symptoms."

true

.

Found this on a website, take it with a pich of salt but worth sharing.

Factors that Promote Remyelination

The Ciliary Neurotrophic Family :

CNTF, leukemia inhibitory factor, cardiotrophin-1, and oncostatin M have been shown to induce a strong promyelinating effect by promoting oligodendrocyte maturation, mediated through the 130 kDa glycoprotein receptor to the CNTF family (86).

Thyroid:

T4 administration to experimental allergic encephalomyelitis animals resulted in an up-regulation of oligodendrocyte progenitors and mature oligodendrocytes in the spinal cord, ofactory bulb, and subventricular zone (11).

Thymus:

Ikehara reports that the success rate of bone marrow transplants in patients over 45 years of age is low, due to the aging of the thymus. BMT plus embryonal thymus grafts can be used to treat late-onset autoimmune disease in mice and can be a valuable strategy for treating older patients with various intractable diseases, including autoimmune diseases. (33). NatCell Thymus, a thymus extract providing a broad spectrum of thymic peptides (www.atrium-bio.com) is being used successfully to restore immune balance in patients with autoimmune disease who are not on immunesuppressants.

Adrenal Support:

Krenn presents a case of Adrenoleukodystrophy that mimicks the symptoms of multiple sclerosis. Both conditions include lesions of the white matter which may be alleviated with adrenal support. (44). Adrenal insufficiency is present in 85% of the childhood cerebral forms and in about 70% of the adult forms of adrenoleukodystrophy (26) and may contribute to white matter lesions in multiple sclerosis as well. Since adrenal extracts may also promote corticosteroid-induced stem cell injury, products such the Atrium adrenal extracts should be used several weeks before stem cell therapy to strengthen the adrenal glands.

Interleukin-1:

Mason writes that interleukin-1 beta promotes remyelination and CNS repair through inducing astrocyte and microglia-macrophage-derived insulin-like growth factor-1 (55).

Interleukin-10:

Interleukin-10 was found to protect against oligodendroglial death evoked by lipopolysaccharide and interferon-gamma. IL-10 downregulates the function of inflammatory cells and promotes survival of progenitors and differentiated oligodendrocytes. (60).

The reason why the cats became sick and developed the neurological problems and loss of myelin in the first place was irradiated food. Can't believe I missed that in dignan's first article.



http://www.forbes.com/feeds/hscout/2009 ... 25606.html


Food irradiation is the process of exposing food to ionizing radiation to kill bacteria, microorganisms, viruses. When this happens, electrons become unpaired and free radicals are released. I talk about the problem with free radicals and nitric oxide in the endothelial paper. The FDA has approved of irradiation for these foods: beef, pork, lamb, poultry, wheat, wheat flour, vegetables, fruits, shell eggs, seeds for sprouting, spices, herb teas. Irradiation is used in over 40 countries....
hmmmm,
AC

_________________
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS

That is awful! Is organic food irradiated?