sou wrote:It is indeed important. However, the study is about cats, which are not closely related to humans. It would be more interesting if it were about monkeys.
If we assume that the human nervous system has the ability to remyelinate, why doesn't it? Is it because the MS process is not halted? If that were the case, Lorenzo Odone's brain (who doesn't have MS at all) should have been remyelinated by now.
Dr. Lucchinetti, leading an international group of collaborating scientists in the MS Lesion Project, identified over 700 people worldwide with MS who underwent brain biopsies. From these tissue samples, they discovered evidence of remyelination in humans. In the process they also uncovered four distinct patterns of tissue destruction in MS. These subtypes explain some of the variability of symptoms between patients. Two of the MS patterns showed evidence of strong natural remyelination. Two did not. They also found that strong remyelination in a given patient in the early-stage MS may not translate into good remyelination in late-stage MS.
cheerleader wrote:My personal paradigm is that the level of venous insufficiency and blockage correlates to the CNS's ability to remyelinate.
sou wrote:But then, adrenoleukodystrophies must have something to do with blocked veins. It is very unlikely. So, why doesn't remyelination of the CNS occur in other conditions?
While looking into why pregnant cats on a special diet of irradiated food began to have problems with movement, including paralysis and vision, University of Wisconsin-Madison researchers found that the felines' nerve fibers had lost the fatty myelin insulation that helps signals pass along these axons.
Once off the diet, though, the cats' bodies reestablished thinner myelin sheaths that allowed the cats to recover fully, but slowly.
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