Theory involving Nitric oxide

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Theory involving Nitric oxide

Postby LR1234 » Thu Apr 02, 2009 12:06 am

I have been thinking about the relationship between Nitric Oxide and its role in MS.

I have seen various studies that suggest that NO blocks the nerve signals and is inflammatory but is reversible.

L'arginine is involved in the formation of Nitric Oxide. I don't know whether the NO is formed because there is too much L'arginine or what the process is.
I do know however that Lysine is antagonistic to L'arginine so maybe by watching the balance of these 2 amino acids (or maybe increasing Lysine) may help to reduce the production of NO. (its all about the ratio)

I need to find studies to see if L-Lysine has been tested a potential therapy for MS. I know that the Herpes virus thrives on L'arginine and by using L-lysine it can be supressed (we also know that the herpes virus is implicated in the pathology of MS and can be activated during excerbations)

Also copaxone contains L-Lysine so maybe that helps with the NO

I recently took a lot of garlic in high doses and had a bad reaction (what I percieved to be a relapse) I looked up the ratio of garlic in terms of L-lysine and arginine and the ratio was higher in L-arginine than L-lysine. The ratio of choclate is also much higher in arginine than lysine (something else I react strongly to)

This has probably all been looked at already I am sure but I would be interested to know of any studies with MS and L-lysine and its relationship to L-arginine and Nitric Oxide.

Has anyone looked into this or tried taking L-lysine. The cautions I know of with L-lysine is too much can have a negative effect on the liver and can also raise cholestrol.
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Postby peekaboo » Thu Apr 02, 2009 8:35 am

Supplements are a balancing act. And like MS, doses of supplements will be subject to individual needs. I wish that there is a service to test all blood markers re: a test that will identify all compnents so one can adjust supplements and doses approriately. But then again I wish that MS never existed.

I take Acetyl L Carnitine for neural support. (brain & Body)

LR1234 do you have any conerns about Acetyl L Carnitine? NOx, or other ???
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Postby LR1234 » Thu Apr 02, 2009 9:08 am

Hi Peekaboo,
Not sure what you mean?! Is a N-acetyl-carnitine involved with nitric Oxide?

L
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Postby peekaboo » Thu Apr 02, 2009 9:19 am

No i don't believe so but L carnitine could be used inplace of the suspect enzymes? for neural support. I am only speculating...
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Postby LR1234 » Thu Apr 02, 2009 9:27 am

so am I:) This is an unknown area for me! The only reason i thought about L-Lysine is because I saw L-arginine is needed to create Nitric oxide and I remembered from my nutrition course that L-lysine lowers the L-arginine levels.
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Postby peekaboo » Thu Apr 02, 2009 9:35 am

L- Your memory does serve you...I looked in my supplement catalogue if it confirms your statement of both enzymes. :D
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Postby peekaboo » Thu Apr 02, 2009 9:36 am

L- oops it does confirm your statements...
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Postby LR1234 » Thu Apr 02, 2009 10:03 am

(by the way they are amino acids not enzymes:) :wink:
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Postby peekaboo » Thu Apr 02, 2009 10:08 am

Thanks for correcting me... i get jarbled sometimes
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Postby Loobie » Thu Apr 02, 2009 2:50 pm

If you look up one of cheerleader's posts, she has written a paper on the role of NO in terms of it's affect on endothelial dysfunction. There's a link in her signature line.
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