Infectious agents, cause/trigger/neither?

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Postby Lyon » Wed Apr 08, 2009 11:20 am

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Postby cheerleader » Wed Apr 08, 2009 12:37 pm

Lars wrote: Our local group which is swelling by the day is 20 miles North of the 37th parallel.
Lars


It's all that group swelling causing the problems, Lars :)
but seriously...high altitude = nitric oxide displacement and vasoconstriction. A problem for the non-indigenous population.

Oops, am I on the infectious thread?
sorry, had to pun-
AC
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Postby Lars » Wed Apr 08, 2009 9:21 pm

Cheer,
I like your thought on it. I have a bit of a problem with Bobs idea that we might be more socially advanced or more sterile than our neighboring states, it make no sense (sorry Bob). I have always felt there to be an altitude connection so maybe Bob has a point and it is not socially normal to live at high altitude. I do know that altitude, exertion at altitude, drastic weather changes, fierce sun and a thin atmosphere are a recipe for HHV outbreaks and guess what else?
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Postby Lyon » Thu Apr 09, 2009 5:20 am

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Postby cheerleader » Thu Apr 09, 2009 7:25 am

In underdeveloped pops, the people have not migrated and have genetic predisposition to less oxygen. Think Tibetans-

The answer for Tibetans who live at altitudes around 14,000 feet is increased nitric oxide (NO) levels. High levels of NO circulate in various forms in the blood and produce the physiological mechanisms that cause the increased blood flow that maintains oxygen delivery despite hypoxia -- low levels of oxygen in the ambient air and the bloodstream. Researchers from Case Western Reserve University and the Cleveland Clinic report that Tibetans have 10 times more NO and have more than double the forearm blood flow of low-altitude dwellers. The findings from a comparison of NO levels in the high and low altitude dwellers are reported in the article, "Higher Blood Flow and Circulating NO Products Offset High-altitude Hypoxia among Tibetans," in the current Proceedings of the National Academy of Sciences (PNAS).

The low barometric pressure of high altitudes generally causes low arterial oxygen content among Tibetans, yet the researchers have found that Tibetans consume oxygen at normal rates.

"We asked how that could be done," said Cynthia Beall, the S. Idell Pyle Professor of Anthropology at Case Western Reserve University. For two decades, Beall has been one of the world's leading researchers in the studies of high altitude adaptation in different populations in Ethiopia, South America and Tibet

http://www.medicalnewstoday.com/articles/87159.php

In Colorado, the people are typically not indiginous, and have lived at high altitude maybe one or two generations at most. Not enough time to develop the endothelial ability. Poor people don't move much...more affluent people do.
My paper talks about nitric oxide and its impact on autoimmune disease-
Back to infections...I'll go play on the other threads now :)
AC
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Postby Lars » Thu Apr 09, 2009 7:37 am

Bob,
I wish you could convince those supposedly in the know that altitude and latitude are connected. I have asked all my Doc's and every forum Doc I can find and have read nothing but denials of the connection. I think it is pretty basic science. Last question on the Social Norm Theory, how does the obvious latitude issue fit in? I can't believe that the 37th parallel is the line in the sand that separates environmental norm and parasitic well being. I do believe the theory is valid it just seems that some dots are hard to connect. There is obviously a latitude issue in all this but for the record, I have always felt the lack of vitamin D as it relates to sun exposure is off the mark. Come visit here and see how fast your skin melts off, we average around 320 sunny days a year. As a secondary point, go to Pennsylvania and see where the sun goes to die.
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Postby Lyon » Thu Apr 09, 2009 9:05 am

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Postby Lars » Thu Apr 09, 2009 1:38 pm

Bob,
Yes, the 37th seems to be the defining latitudinal parallel used in most latitude related data. In my case it is basically the Colorado - N.M. border.
Good point on data averages, it is why I don't believe in or take the approved therapies.
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Postby Lyon » Thu Apr 09, 2009 4:25 pm

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Postby Lars » Thu Apr 09, 2009 8:30 pm

Bob,
I had saved a US/MS incidence map from the mscenter but the link seems to be compromised. http://mscenter.ucsf.edu/images/technic ... graphy.jpg
It was a great, and recent map which showed scary data from Colorado. I have searched forwards and backwards for it and can't find it. OK, to address a different aspect of your last post, I spent 25 years in the Professional Rodeo Cowboys association and it seems my life revolved around Porta-Potties. When I wasn't in the arena I was in the mountains camping, skiing and climbing, sorry no flush and plenty of dirt! Oh, I spent my youth on a ranch with an outhouse and have had at least 4 residences that an outhouse was the only privy. I should be the last person in the world to succumb to the flush toilets cause MS theory. I should have Typhoid not MS. I'm not really a hick, I just like to spend time alone in the mountains. Wow I just read over this and the only thing I can say is; too much information. I must really like you.
Be Well and Stay Dirty,
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Postby Lyon » Fri Apr 10, 2009 5:40 am

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Postby Lars » Fri Apr 10, 2009 7:31 am

Bob,
I know you and and Jamie were investigating whip worm therapy, any luck?
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Postby Lyon » Fri Apr 10, 2009 12:49 pm

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