In underdeveloped pops, the people have not migrated and have genetic predisposition to less oxygen. Think Tibetans-
Quote:
The answer for Tibetans who live at altitudes around 14,000 feet is increased nitric oxide (NO) levels. High levels of NO circulate in various forms in the blood and produce the physiological mechanisms that cause the increased blood flow that maintains oxygen delivery despite hypoxia -- low levels of oxygen in the ambient air and the bloodstream. Researchers from Case Western Reserve University and the Cleveland Clinic report that Tibetans have 10 times more NO and have more than double the forearm blood flow of low-altitude dwellers. The findings from a comparison of NO levels in the high and low altitude dwellers are reported in the article, "Higher Blood Flow and Circulating NO Products Offset High-altitude Hypoxia among Tibetans," in the current Proceedings of the National Academy of Sciences (PNAS).
The low barometric pressure of high altitudes generally causes low arterial oxygen content among Tibetans, yet the researchers have found that Tibetans consume oxygen at normal rates.
"We asked how that could be done," said Cynthia Beall, the S. Idell Pyle Professor of Anthropology at Case Western Reserve University. For two decades, Beall has been one of the world's leading researchers in the studies of high altitude adaptation in different populations in Ethiopia, South America and Tibet
http://www.medicalnewstoday.com/articles/87159.php
In Colorado, the people are typically not indiginous, and have lived at high altitude maybe one or two generations at most. Not enough time to develop the endothelial ability. Poor people don't move much...more affluent people do.
My paper talks about nitric oxide and its impact on autoimmune disease-
Back to infections...I'll go play on the other threads now
AC
_________________
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS 
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