But if it depends on how you time the MRI, and it's hit or miss whether you see enhancement, what good is this as a data point?
Thus, a need exists for alternative MRI measures that more accurately monitor clinical disease activity and measure the efficacy of DMTs. In this regard, advanced MRI measures allow more sensitive quantification of microscopic neuronal damage present in normal-appearing brain tissue and serve as more reliable surrogate markers for neuronal injury and repair.
…....neuronal or ...axonal damage has been revealed by MRI to occur relentlessly from disease onset
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