OK, really quickly..I don't want to tick folks off. (I actually meant leaving this thread alone...but I'm staying around on the CCSVI thread.)
I think there is a certain percentage of the population walking around with congenital venous blockage...yet they do not have MS. They may get headaches, fatigue, but no break in the blood brain barrier. This leads to my endothelial research. When there are outside issues such as stress, bad fats, low vit. D, toxins, etc...the blood hypercoagulates, ESR rates go up, CRP goes up, and this creates more serious perfusion and venous congestion. Here is our typical, industrialized western lifestyle exacerbating a condition that might have remained benign. This leads to the break in the BBB, activation of the immune system and MS.
About 3% of the world has venous insufficiency in the legs, but not everyone develops venous ulcers. A smaller percentage get this:
http://surgery.med.nyu.edu/wound/condit ... nous-ulcer
What Zamboni and Dake believe is that chronic venous insufficiency in the CNS is like venous insufficiency in other parts of the body...the hepatic system, the legs, etc. It's just that no one has really looked at these veins before.
Dr. Dake was blown away by the logic of it all...smacking his head, saying, why hasn't anyone thought of this paradigm before? Now that we have MRV, dopplers, higher resolution MRI, the picture becomes clearer.
Jeff's been stable, taking his supplements, exercising, stress reduction...but he still has extreme fatigue, depression issues and leg pain from his one cervical spine lesion (which sits parallel to his jugular blockage) BUT...his jugular veins never worked right. His blood levels were terrible at dx- high ESR, high crp, high liver enzymes. His jugular blockage was exacerbated by stress, bad diet, and a high altitude vacation. Now his blood numbers are perfect and he's stable. It took 43 years of living to manifest as his first MS flare.
Hope this makes a bit of sense...