100% EBV infection in MS

If it's on your mind and it has to do with multiple sclerosis in any way, post it here.

Postby marcstck » Mon Aug 03, 2009 11:32 am

LiquidSkin wrote:I have never had EBV or Mono, I even double check with my mom to see if I had it really young, yet again nope.

I was a really healthly kid, so I wonder if there are other things that might be triggers.


The vast majority of people infected with EBV have never had Mono. Many times, the infection can be mistaken for a cold or flu, and it also can be completely asymptomatic.

The only way for you to know whether or not you're infected with EBV would be to have blood tests looking for the virus. As this research indicates, if you have MS, you can bet your bottom dollar that you have EBV...

I never had Mono, but I am infected with EBV...
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Postby cheerleader » Mon Aug 03, 2009 12:36 pm

An interesting correlation...in reading up about possible hypoxia (oxygen deprivation to the brain) in CCSVI, found this...

Hypoxia can contribute to the induction of the Epstein-Barr virus (EBV) lytic cycle

Results: Hypoxia treatment not only increased the expression of the EBV immediate-early protein Zta (which mediates the switch between the latent and lytic form of infection), but also increased the number of EBV DNA copies in B95-8 cells. Conclusions: EBV in latent infection can be activated to lytic infection by hypoxia.

http://cat.inist.fr/?aModele=afficheN&cpsidt=18173331
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Postby jimmylegs » Mon Aug 03, 2009 12:42 pm

selenium status is low in ms, soil selenium distribution is pretty variable spatially, and selenium helps you not to succumb to viruses.
here's an interesting article, not peer reviewed or anything, but it has a few maps of soil selenium status and virus (avian flu) outbreaks:
http://www.369.com.cn/369/aids/index.htm

journal stuff about selenium and viruses:

http://www.springerlink.com/content/g437v703r60j3322/
"The clinical study among 226 Hepatitis B Surface Antigen (HBsAg)-positive persons provided either 200 μg of Se in the form of selenized yeast tablet or an identical placebo of yeast tablet daily for 4 yr showed that 7 of 113 subjects were diagnosed as having PLC in the placebo group, whereas no incidence of PLC was found in 113 subjects supplemented with Se. Again on cessation of treatment, PLC developed at a rate comparable to that in the control group, demonstrating that a continuous intake of Se is essential to sustain the chemopreventive effect."

http://www.fasebj.org/cgi/content/short/15/8/1481
"In conclusion, mice fed a diet deficient in Se suffer much more severe lung pathology after infection with the influenza virus than Se-adequate controls. "

http://www.ncbi.nlm.nih.gov/pubmed/12561431
"The transformation of umbilical blood B lymphocytes stimulated by EB virus and expression of EBV-EA in Raji cells may be significantly inhibited by Se-rich rice extract, suggesting that Se-rich rice can be used for preventing nasopharyngeal carcinoma."
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Postby ElMarino » Wed Aug 05, 2009 4:59 am

cheerleader wrote:An interesting correlation...in reading up about possible hypoxia (oxygen deprivation to the brain) in CCSVI, found this...

Hypoxia can contribute to the induction of the Epstein-Barr virus (EBV) lytic cycle





Interesting! Thanks for sharing..
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Postby Terry » Wed Aug 05, 2009 6:43 am

Jimmylegs,
How much Selenium are you taking? What should I buy? I bet you've already said, and sorry, but please repeat.
Thanks!
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Postby jimmylegs » Wed Aug 05, 2009 12:04 pm

hi terry i take 200 - 400 mcg per day and i am still awaiting results from my 'baseline' selenium test.
you are supposed to be able to get 200 per day by eating 3 brazil nuts. and i hear egg yolks are supposed to be decent too. i imagine that is quite variable depending on soil selenium where the nuts or chicken feed are grown.
i'll post my results, if i ever get them, on my regimen thread, cheers terry :)
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Postby Terry » Wed Aug 05, 2009 6:51 pm

As always, Thank you JL.
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Postby jimmylegs » Wed Aug 05, 2009 7:21 pm

found some more info terry, REALLY GOOD:

http://www.jacn.org/cgi/content/full/20/1/1
Nutritional Selenium Supplements: Product Types, Quality, and Safety

"Selenium supplements contain selenium in different chemical forms. In the majority of supplements, the selenium is present as selenomethionine...
Current evidence favors selenomethionine over the other forms of selenium...
Since more than 80% of the total selenium in seleniferous corn, wheat and soybeans consists of L(+)-selenomethionine [4], this amino acid is the most appropriate supplemental form of selenium...
In 1983... selenomethionine-rich yeast was chosen as the source of selenium for a large-scale cancer prevention trial [17].
This trial showed that taking an extra 200 micrograms of selenium per day significantly lowered the risks of developing prostate, lung and colorectal cancer...
In 1984, synthetic selenomethionine became available...
Since selenomethionine, like all amino acids, can exist in the L- and in the D-form and since only the L-isomer occurs naturally in foods, this form is preferable for use in supplements intended for humans...
The ‘Lowest Adverse Effect Level’ (LOAEL), defined as the ‘average daily selenium intake causing individuals within a population to develop overt signs of toxicity,’ is believed to be in the order of 1540±653 mcg/d."
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Postby euphoniaa » Sun Aug 09, 2009 11:56 am

marcstck wrote: This research does not show that EBV is the sole cause of multiple sclerosis. It does strongly suggest, though, that EBV plays a role in the MS disease process. It is likely that EBV in combination with a genetic predisposition and some other environmental trigger (such as vitamin D deficiency, or another chronic infection) sets off the immune cascade that we know as multiple sclerosis.


Ever since my dx, I've pretty much disregarded the EBV possibility because I'd had negative mono testing long ago. But several posts in this thread, like the one above, led me to review my memories a bit more.

Of course, my experience lends little to no enlightenment to the topic, but...I do like to tell stories. :) When I was in college (about age 20), I roomed for awhile with my sister, who came down with mono. I took care of her until they finally sent her contagious self home to recover, although we were both sick at the same time. They tested me for mono 2 or 3 times, but I was always negative, even though I continued to have monthly colds/swollen glands/laryngitis like I had all the way through college.

The next fall, I continued with the same swollen glands in my neck that I'd had with every cold since childhood, until the school clinic insisted I get a tonsillectomy as I turned 21. I had no more colds for the rest of the winter!

However, by the next fall, around my 22nd birthday, my sister got to return the caretaker favor when she and a friend had to rescue me at work and literally carry me to the ER when I suddenly couldn't walk (the main reason I date my MS that far back).

So...the idea of chronic infections combined with my family's sickly genetics has caught my attention. In fact, my cousin who also has MS lived close by us in the same dorm. And no, my 2 sisters have never been tested for MS, although I'm generally healthier & more mobile than they are. They really don't want to know...
Dx'd with MS & HNPP (hereditary peripheral neuropathy) 7/03 but must have had MS for 30 yrs before that. I've never taken meds for MS except 1 yr experiment on LDN. (I found diet, exercise, sleep, humor, music help me the most.)
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