I was wondering if mast cells are trying to Endocytosis tnf-alpha at neural lessions as I found this article.
Which I think means mast cells can store tnf-alpha. As most research focuses on mast cells as producers of tnf-alpha although other cells can aswell. I have also heard of research interest into tnf-alpha and tace around lession sites.
Also found these articles on tnf-alpha
http://www.pubmedcentral.nih.gov/articl ... id=1853008
http://www.nature.com/mp/journal/v7/n8/ ... 1120a.html
I also think tnf damages blood vessels at higher levels
However, this research seems to say tnf-alpha at a certain level is protective but can become harmful at higher levels.
So in summary I was wondering if mast cells regulate tnf-alpha in the inter cellular space and if so does it work in MS'ers