Inexpensive Hypertension Drug Could Be Multiple Sclerosis Tr

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Inexpensive Hypertension Drug Could Be Multiple Sclerosis Tr

Postby arthurherr » Wed Aug 19, 2009 10:31 pm

This one is currious!
Inexpensive Hypertension Drug Could Be Multiple Sclerosis Treatment, Study Suggests

http://www.sciencedaily.com/releases/20 ... 184437.htm

First authorship of the paper is shared by two postdoctoral researchers in Steinman's lab: Michael Platten, MD, and Sawsan Youssef, PhD.
Professor Lawrence Steinman, MD-This fellow has been around the block on MS for quite awhile.
The paper is Quite a departure from his regular "funding streams", Reminds me of the blood circulatory work from that Italian doctor that was a hit "topic" for awhile here.
In any event-good to see a departure from esoteric research into practical
almost immediate shift in thinking!
But,same old mouse model.My brother speaks often with NIH.years ago he asked me what I thought of MS research-I said "not much".Gotta find new model!He does nano tech and works with them on self assembly/drug delivery to brain,amongst other "stuff".hehe.

Currious.
Enjoy
A

Oh yeah,Jimmylegs this one will give you your "TREGS".
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Postby ElMarino » Thu Aug 20, 2009 6:34 am

I was put on a similar ACE inhibitor (Ramipril) two years prior to my first MS symptoms and for the following four years into the MS (I no longer take them) but they don't appear to have helped much as I accrued much disability from relapses throughout this time. To my mind it might only help mice with EAE, unfortunately..
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Postby arthurherr » Thu Aug 20, 2009 12:25 pm

ElMarino,

The current model is an illusory figment.Agreed!
Gonna take a look at the molecular structures of the varriing ACEs.
See if any dicernable difference from one mentioned in this paper versus
others.

Warmest,A
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Wait guys, don't dismiss this so quickly!

Postby radeck » Sat Aug 29, 2009 6:11 am

I totally agree that the current animal models for MS are imperfect, however I very much disagree with those here that seem to claim we should simply neglect them! Btw, there are *several* EAE models, some mimicking more the chronic progressive, some more the inflammatory component. To dismiss all those models as completely useless is irresponsible, as would be claiming they're perfect.

What's VERY interesting about the Lisinoprile research is that it does something similar to Copaxone, however much more efficiently, i.e. it shifts T cell populations from inflammatory to regulatory. At least as importantly, the researchers were able to show that it targets Th1 and Th17 in particular, the channels now made primarily responsible for demyelinating auto-immune disease.

Also, note that Lisiniprile completely reversed disability in rodents (i.e. they go back to EDSS=0), as opposed to Copaxone, which only reduces it in rodents, and has no proven impact on disability in humans.

One question that would be really interesting to answer is whether those who happen to have MS as well as hypertension, AND have used Lisinopril for a while, have slower MS progression than average MS'ers.
Last edited by radeck on Tue Sep 13, 2011 9:27 am, edited 1 time in total.
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Postby LR1234 » Sat Aug 29, 2009 7:47 am

I would love to speak to those MSers too that have tried Liniospril.
Say if you are like me and have hypotension? I suppose the drug might be dangerous to take....
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Postby radeck » Sun Aug 30, 2009 12:58 pm

LR1234 wrote:I would love to speak to those MSers too that have tried Liniospril.
Say if you are like me and have hypotension? I suppose the drug might be dangerous to take....


I have started taking it 4 days ago at low dose. I'm undecided between this and Metformin as self-experiments. I have normal blood pressure so am monitoring it very frequently. Will post here if things go in an interesting direction for me.
Last edited by radeck on Sat Sep 26, 2009 10:06 am, edited 1 time in total.
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Postby LR1234 » Sun Aug 30, 2009 3:21 pm

Cool...Be careful Radeck.
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Postby patientx » Sun Aug 30, 2009 3:51 pm

radeck wrote:I have started taking it 4 days ago at low dose. I have normal blood pressure so am monitoring it closely. I'm undecided between this and Metformin as self-experiments. I have normal blood pressure so am monitoring it very frequently. Will post here if things go in an interesting direction for me.


Did you get this prescribed by a doctor?
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Postby radeck » Mon Aug 31, 2009 8:04 am

Yes, but I think there may also be online pharmacies that sell it without prescription. Not sure if that's legal though.
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