Placebos Are Getting More Effective

If it's on your mind and it has to do with multiple sclerosis in any way, post it here.

Placebos Are Getting More Effective

Postby zap » Wed Aug 26, 2009 12:25 pm

Very interesting article about the history and changing power of placebo medications ...

http://www.wired.com/medtech/drugs/maga ... ntPage=all
User avatar
zap
Family Elder
 
Posts: 326
Joined: Mon Apr 20, 2009 3:00 pm

Advertisement

Postby notasperfectasyou » Wed Aug 26, 2009 12:48 pm

So thinking ...... of how can I pressure Lyon to comment on this - hummmmm.

Where are we now on the possibility of bringing back Tovaxin? Opexa still exists, but I don't follow it anymore. Ken
User avatar
notasperfectasyou
Family Elder
 
Posts: 774
Joined: Thu Feb 09, 2006 4:00 pm
Location: Northern Virginia

Postby Lyon » Wed Aug 26, 2009 2:00 pm

..
Last edited by Lyon on Tue Jun 21, 2011 5:47 pm, edited 1 time in total.
Lyon
Family Elder
 
Posts: 6063
Joined: Wed May 03, 2006 3:00 pm

Postby Lyon » Wed Aug 26, 2009 7:53 pm

...
Last edited by Lyon on Tue Jun 21, 2011 5:47 pm, edited 1 time in total.
Lyon
Family Elder
 
Posts: 6063
Joined: Wed May 03, 2006 3:00 pm

Postby jimmylegs » Thu Aug 27, 2009 8:01 am

this is going back a few years and i don't remember what was being tested, but the placebo pill was a quercetin capsule. spare me!!!
jimmylegs
Volunteer Moderator
 
Posts: 9003
Joined: Sat Mar 11, 2006 4:00 pm

Postby notasperfectasyou » Thu Aug 27, 2009 9:50 am

Lyon wrote:something more specific??


I was just referencing that one of the issues everyone got upset about was that the trial had a much better than historically normal placebo response. At least that what I remembered. Ken
User avatar
notasperfectasyou
Family Elder
 
Posts: 774
Joined: Thu Feb 09, 2006 4:00 pm
Location: Northern Virginia

Re: Placebos Are Getting More Effective

Postby NHE » Thu Aug 27, 2009 4:46 pm

notasperfectasyou wrote:I was just referencing that one of the issues everyone got upset about was that the trial had a much better than historically normal placebo response. At least that what I remembered. Ken


Opexa's explanation for the observation that you're referring to was that the patients were randomized to the treatment and placebo groups independently of their lesion burden. As it turned out, since lesion burden wasn't taken into account, the patients in the placebo group had an overall lower lesion burden than the treatment group. This characteristic of the study groups and was just by chance. A larger study population may have allowed for a more equal distribution of patient types between the two study groups, i.e., equalized the lesion burden. With a smaller study, such as Opexa's Tovaxin trial, it may have been benefical to have taken lesion burden into account when assigning patients to either the treatment or placebo groups. This would have assured that both groups were starting out on equal ground and would have made for a better assessment of the treatment's potential effectiveness.

NHE
User avatar
NHE
Volunteer Moderator
 
Posts: 3334
Joined: Sat Nov 20, 2004 4:00 pm

Postby zap » Fri Aug 28, 2009 2:21 pm

Mind-body Connection In Placebo Surgery Trial Studied By University Of Denver Researcher

http://www.sciencedaily.com/releases/20 ... 084240.htm
User avatar
zap
Family Elder
 
Posts: 326
Joined: Mon Apr 20, 2009 3:00 pm

Re: Placebos Are Getting More Effective

Postby notasperfectasyou » Fri Aug 28, 2009 2:27 pm

NHE wrote:Opexa's explanation for the observation that you're referring to was that the patients were randomized to the treatment and placebo groups independently of their lesion burden. As it turned out, since lesion burden wasn't taken into account, the patients in the placebo group had an overall lower lesion burden than the treatment group. This characteristic of the study groups and was just by chance. A larger study population may have allowed for a more equal distribution of patient types between the two study groups, i.e., equalized the lesion burden. With a smaller study, such as Opexa's Tovaxin trial, it may have been benefical to have taken lesion burden into account when assigning patients to either the treatment or placebo groups. This would have assured that both groups were starting out on equal ground and would have made for a better assessment of the treatment's potential effectiveness.

NHE


Dang! That is impressive.
User avatar
notasperfectasyou
Family Elder
 
Posts: 774
Joined: Thu Feb 09, 2006 4:00 pm
Location: Northern Virginia

Re: Placebos Are Getting More Effective

Postby Lyon » Fri Aug 28, 2009 4:12 pm

..
Last edited by Lyon on Tue Jun 21, 2011 5:48 pm, edited 1 time in total.
Lyon
Family Elder
 
Posts: 6063
Joined: Wed May 03, 2006 3:00 pm

Postby fernando » Tue Sep 08, 2009 5:37 am

http://www.sciencebasedmedicine.org/?p=1248

Interesting discussion by a blogger regarding this article. The best part is in the comments section where the author himself addresses several issues.
User avatar
fernando
Family Elder
 
Posts: 228
Joined: Wed Jul 15, 2009 3:00 pm
Location: Argentina


Return to General Discussion

 


  • Related topics
    Replies
    Views
    Last post

Who is online

Users browsing this forum: No registered users


Contact us | Terms of Service