Just_Me wrote:Which of the CRAB drugs is supposed to be best? The doctor said I have progressive MS & told me Rebif or Copaxone would be right for me but I can't find any info online about which drugs are for PPMS.
The Four Courses of MS
People with MS can typically experience one of four disease courses, each of which might be mild, moderate, or severe.
People with this type of MS experience clearly defined attacks of worsening neurologic function. These attacks—which are called relapses, flare-ups, or exacerbations —are followed by partial or complete recovery periods (remissions), during which no disease progression occurs. Approximately 85% of people are initially diagnosed with relapsing-remitting MS.
This disease course is characterized by slowly worsening neurologic function from the beginning—with no distinct relapses or remissions. The rate of progression may vary over time, with occasional plateaus and temporary minor improvements. Approximately 10% of people are diagnosed with primary-progressive MS.
Following an initial period of relapsing-remitting MS, many people develop a secondary-progressive disease course in which the disease worsens more steadily, with or without occasional flare-ups, minor recoveries (remissions), or plateaus. Before the disease-modifying medications became available, approximately 50% of people with relapsing-remitting MS developed this form of the disease within 10 years. Long-term data are not yet available to determine if treatment significantly delays this transition.
In this relatively rare course of MS (5%), people experience steadily worsening disease from the beginning, but with clear attacks of worsening neurologic function along the way. They may or may not experience some recovery following these relapses, but the disease continues to progress without remissions.
Since no two people have exactly the same experience of MS, the disease course may look very different from one person to another. And, it may not always be clear to the physician—at least right away—which course a person is experiencing.
Frank wrote:...So it might be worth to consider to give the alternatives a try, say take LDN, ABX, EGCG, Vit D etc. for half a year and see how things are going and if it turns out to be not satisfying, you could still switch to any of the CRABs.
But personally I would find the prospect the CRABs can offer too gloomy to be my fist choice....
Just_Me wrote:I don't like the dismal 30% improvement the CRAB drugs offer but I am a little afraid of waiting 6mo to start.
Based on this review, the included studies showed that ss-interferon treatment was not associated with reduced disability progression in PPMS patients.
euphoniaa wrote:Just_Me wrote:I don't like the dismal 30% improvement the CRAB drugs offer but I am a little afraid of waiting 6mo to start.
I hate to tell you, JM, but none of the MS meds promise any kind of "improvement" whatsoever. In fact, the side effects are likely to make someone feel worse, even when they "work." The "30%" that's usually mentioned (give or take a few percents), refers to the fact that trials have shown that there was an average 30% or so reduction in the overall relapse rates, etc., of those in the trials. They have since learned how to keep re-doing studies against one another to make one sound more effective than another in other ways also.
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