http://www.reuters.com/article/2011/08/ ... 1J20110803
"Pyott said he expects U.S. regulators this year to approve Botox for those whose overactive bladder is caused by multiple sclerosis…"
Isn't the action of Botox to paralyze muscles? The muscles of the bladder, intestines, blood vessels, and even the skeletal muscles used in all kinds of movement (walking, everyday activities, etc.) could be at the root of the problem in MS because of the elevated insulin secretion in insulin resistance. Can someone tell me why MS was ever pigeonholed as a neurological disease? If MS were strictly neurological, why would Kegel exercises (which strengthen the pelvic MUSCLE floor) improve bladder problems?
The entire article:
Overactive bladder next Botox frontier
By Ransdell Pierson
NEW YORK | Wed Aug 3, 2011 5:22pm EDT
NEW YORK (Reuters) - Overactive bladders later this year could become the next big frontier for Botox, the anti-wrinkle drug, and significantly boost sales of the $1.5 billion-a-year product, according to Allergan Inc Chief Executive David Pyott.
Allergan earlier on Wednesday reported profit growth for the second-quarter, fueled largely by sales of Botox to smooth wrinkles and for a growing range of medical uses.
Overactive bladder, caused by uncontrollable contractions of the bladder, causes frequent urination, urgent need to urinate and inability to control urination.
"Current drugs for overactive bladder just don't work that well," Pyott said in an interview, "and studies show that after a year 70 percent of patients don't respond to treatment."
Standard treatments, pills called anticholinergics, including oxybutynin and GlaxoSmithKline PLC's Vesicare, are associated with dry mouth and can cause constipation and other side effects.
A single injection of Botox into the bladder can provide significant relief for up to nine months and significantly improve quality of life, Pyott said, particularly for adults who now need to wear diapers.
Pyott said he expects U.S. regulators this year to approve Botox for those whose overactive bladder is caused by multiple sclerosis and spinal cord injury, which together number about 350,000 patients in the United States.
Several years later, Allergan hopes to win approval to market it to a broader population of patients with overactive bladder.
Pyott declined to forecast sales of Botox for overactive bladder but said Wall Street analysts are projecting annual sales of up to $500 million. "For a company with a revenue base of $5.2 billion to $5.4 billion, another $500 million franchise is kind of cool," he said.
Botox, whose active ingredient is a toxin that blocks nerve signals, gets about half its sales from reducing wrinkles and the rest from a number of medical uses, including treatment of migraine headaches and spasticity.
The product's second-quarter sales rose 16 percent to $418 million, helped by its recent approval to treat migraines and a somewhat stronger economy, which enabled more patients to pay out of pocket for cosmetic uses.
Allergan said on Wednesday that net income rose to $249 million, or 79 cents per share, from $241 million, or 78 cents per share, in the year-earlier quarter.
Excluding special items, the company earned 96 cents per share. Analysts on average expected 95 cents, according to Thomson Reuters I/B/E/S.
Sales rose almost 14 percent to $1.40 billion, topping Wall Street forecasts of $1.34 billion. They would have increased 9.6 percent if not for the weaker dollar, which drives up the value of sales in overseas markets.
"Strong top-line trends continue," JP Morgan analyst Chris Schott said in a research note, "and we expect these dynamics to continue throughout 2011."
Schott said Allergan boosted its 2011 overall sales forecast by $120 million to $170 million. But he noted the company reported higher-than-expected spending in the second quarter on sales, general and administrative expenses.
Sales of prescription eye medicines, by far the company's biggest business, rose 14 percent to $658 million.
Sales of medical devices rose 12 percent to $245 million, fueled by demand for breast implants and dermal fillers.
But sales of the company's Lap Band product, to treat obesity, continued to decline, as did sales of the company's Latisse eyelash-growth product.
Allergan nudged up its full-year profit forecast to between $3.59 and $3.63 per share, excluding special items. It had previously expected $3.56 to $3.62.
Allergan closed up 3.1 percent at $79.79 on the New York Stock Exchange.
(Editing by Dave Zimmerman, Lisa Von Ahn and Steve Orlofsky)
(This story corrects paragraph 6 to say that Botox may work up to nine months (not a year) for overactive bladder, and corrects in paragraph 8 that the company hopes to sell the drug later to a broader group of OAB patients (but not for nocturia))