i had two spinal lesions consistent with b12 deficiency and 9 cranial lesions including the ominous 'dawson's fingers'
b12 deficiency is a major differential dx when assessing a potential ms patient. the neuro at the neuromuscular clinic and staff at the ms clinic didn't really listen to me about my b12 deficiency history. i own that i would not stop frantically supplementing b12 at the time so that they could get a clean read of my background levels! my family doc's computer program had a glitch which meant she did not confirm my b12 deficiency back story. i wasn't able to show her the result and point out the glitch til months later. my neuro told me that my cranial lesions were not consistent with b12 deficiency.
at the time i did not yet know about all my other deficiencies so i wasn't good at arguing about the potential causes of the cranial lesions. now i can hypothesize that zinc deficiency can also lead to brain lesions.
i remember when i was at my most cognitively impaired a couple years after dx, and just in the process of figuring out my zinc issues, that an MRI had shown a more active lesion in my brain. i described some of my then current cognitive symptoms to my neuro and asked if it was plausible that they were connected with the location in my brain of this more active lesion. he said yes.
at this stage i am aware of the dangers of imbalances with respect to copper and zinc. i searched for the following terms: serum zinc cranial lesions mri
and found this study (wilson's disease involves excess copper, which is generally going to mean too much copper in relation to zinc):
so it's only a case study, but telling that they took this patient with excess copper and brain lesions, provided him with zinc therapy (which would logically bring copper down and restore a balanced copper zinc ratio) and the brain lesions seen on MRI resolved.
Wilson's disease: resolution of MRI lesions following long-term oral zinc therapyhttp://onlinelibrary.wiley.com/doi/10.1 ... x/abstract
"A 28-year-old man with Wilson's disease developed neurological deterioration after a low-dose of d-penicillamine treatment for 2 weeks. He showed an akinetic rigid syndrome with generalized dystonia. Brain magnetic resonance images (MRI) on T2 and proton weighted images showed an increased signal intensity over the thalamus, basal ganglia and brainstem, especially the midbrain and pons. After treatment had been changed to zinc sulphate, the akinetic-rigid syndrome and dystonia were improved slowly in the following 4 years. Serial MRI studies showed a gradual resolution of the lesions. His current neurological status was almost normal except for dysarthria and mild intention tremor."
so, in my case i hypothesize that my constellation of brain and spine lesions were from not just b12 deficiency but also poor copper zinc balance, potentially among other things also, stemming from my chronic nutritionally imbalanced diet.
so there's one scenario where mri findings may not be related to ms. (didn't stop the docs from dx'ing me with it though. i just chose not to take the meds! lots of good whole food nutrition instead!