Celeste485 wrote:Here is more about pork.
I have a journal of my daughter’s foods/activities/illnesses, for example, I don’t write “milk” because we drink almond milk all the time so there is no need to write this down. I write all sugars, fructose in excess of 2 fruits per day, meats, if she eats too many carbs, etc... And last week we had pork again-soup with some pork meat in it and it shows that the following day my daughter got some sinus issue. It lasted only half a day and now this. I am sure pork somehow is involved with the sinuses.
Here is where it becomes tricky. Last week she didn’t have any sugar or any sweet drinks, excess fructose but before she got the sinus she spent 20 hours in bed just lying and doing nothing. This time she had little sugar on Halloween, just two candies, pork for dinner on Halloween and some cold pork with sandwich for lunch on Friday, then on Friday evening she had sinus problem. That Friday after school she spent the entire afternoon/evening in bed doing nothing. The entire weekend she didn’t go anywhere except for 2 hours to the mall with friends and they had Pepperoni pizza. Anyway, the activity or luck of it maybe very important here.
I used to have similar thing with my blood pressure. Always in the evening, and always after prolonged sitting and pressing my back onto a pillow or couch, or early in the morning after hours of sleeping. I could always feel discomfort in my lower back prior to it, and all that lasted few days. The bp medicine was of no help during that time. If I was sitting long time without pressing the back, my blood pressure was okay, the pressing was always causing the blood pressure to rise. I didn't have sinus problem but I didn't feel well either. Otherwise my blood pressure was under control. I had 3 different doctors and none of them could explain it. It is very possible that my blood pressure rises after eating pork meat. I think I am going to check on this.
The meat can cause some inflammation, sinus but does it cause MS? What if there is a pressure that causes the lesions, like blood pressure?
BACKGROUND: Zinc deficiency is known to result in epithelial barrier leak in the GI tract. Precise effects of zinc on epithelial tight junctions (TJs) are only beginning to be described and understood. Along with nutritional regimens like methionine-restriction and compounds such as berberine, quercetin, indole, glutamine and rapamycin, zinc has the potential to function as a TJ modifier and selective enhancer of epithelial barrier function.
AIMS: The purpose of this study was to determine the effects of zinc-supplementation on the TJs of a well-studied in vitro GI model, CACO-2 cells.
METHODS: Barrier function was assessed electrophysiologically by measuring transepithelial electrical resistance (R(t)), and radiochemically, by measuring transepithelial (paracellular) diffusion of (14)C-D-mannitol and (14)C-polyethyleneglycol. TJ composition was studied by Western immunoblot analyses of occludin, tricellulin and claudins-1 to -5 and -7.
RESULTS: Fifty- and 100-μM zinc concentrations (control medium is 2 μM) significantly increase R(t) but simultaneously increase paracellular leak to D-mannitol. Claudins 2 and 7 are downregulated in total cell lysates, while occludin, tricellulin and claudins-1, -3, -4 and -5 are unchanged. Claudins-2 and -7 as well as tricellulin exhibit decreased cytosolic content as a result of zinc supplementation.
CONCLUSIONS: Zinc alters CACO-2 TJ composition and modifies TJ barrier function selectively. Zinc is one of a growing number of "nutraceutical" substances capable of enhancing epithelial barrier function, and may find use in countering TJ leakiness induced in various disease states.
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