that's a million dollar question, and everyone has to come up with their own way to cope. what works for me is to first focus on the things I CAN do, not on the things I can't. and I don't always put up the front of a happy face for those I'm closest to. denying it to them makes it too easy to deny to myself. I think they appreciate the honesty once in a while, and it feels good to be able to admit when I'm having a rough time.
I haven't had to ask for much help yet, fortunately, but I hope I will do so when I need it. I doubt you'd have qualms about helping someone else in need--why shouldn't you ask for help if you need it??
in any case, there's a great community here, lots of good information, and helpful lessons in these threads on how to cope. good luck.